Effect of Feeding Frequency on Glucose and Insulin Metabolism and Substrate Partitioning

This study has been completed.
Nederlandse Zuivel Organisatie
Information provided by:
Maastricht University Medical Center
ClinicalTrials.gov Identifier:
First received: December 16, 2009
Last updated: July 22, 2010
Last verified: July 2010
The purpose of this study is to determine the effect of feeding frequency on glucose and insulin metabolism and substrate partitioning.

Condition Intervention
Glucose Metabolism
Dietary Supplement: low feeding frequency (3x)
Dietary Supplement: High feeding frequency (14x)

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Open Label
Primary Purpose: Prevention
Official Title: Effect of Feeding Frequency on Glucose and Insulin Metabolism and Substrate Partitioning

Resource links provided by NLM:

Further study details as provided by Maastricht University Medical Center:

Primary Outcome Measures:
  • Glucose and insulin metabolism [ Time Frame: 24 h ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Substrate partitioning and metabolic markers [ Time Frame: 24 h ] [ Designated as safety issue: No ]

Enrollment: 14
Study Start Date: October 2009
Study Completion Date: June 2010
Primary Completion Date: March 2010 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: low feeding frequency (3x) Dietary Supplement: low feeding frequency (3x)
3 meals a day
Experimental: High feeding frequency (14x) Dietary Supplement: High feeding frequency (14x)
14 meals a day


Ages Eligible for Study:   18 Years to 35 Years
Genders Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • BMI: 18.5-25 kg/m2 (lean)
  • Gender: Male
  • Age: subjects has to be older than 18 and including 35 years old
  • Caucasian

Exclusion Criteria:

  • Metabolic abnormalities such as:

    1. Lactose intolerant
    2. Diabetes Mellitus
    3. Hypertension
    4. Hypotension
    5. Cardiovascular diseases
    6. Asthma and other obstructive pulmonary diseases
    7. Elevated fasting blood glucose level
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Please refer to this study by its ClinicalTrials.gov identifier: NCT01034293

University of Maastricht
Maastricht, Limburg, Netherlands, 6229 ER
Sponsors and Collaborators
Maastricht University Medical Center
Nederlandse Zuivel Organisatie
Principal Investigator: WHM Saris, Prof. Dr. Maastricht University
  More Information

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Prof. dr. WHM Saris, University of Maastricht
ClinicalTrials.gov Identifier: NCT01034293     History of Changes
Other Study ID Numbers: MEC 09-3-032 
Study First Received: December 16, 2009
Last Updated: July 22, 2010
Health Authority: Netherlands: The Central Committee on Research Involving Human Subjects (CCMO)

Keywords provided by Maastricht University Medical Center:
feeding frequency
insulin metabolism
glucose metabolism
substrate partitioning

ClinicalTrials.gov processed this record on May 22, 2016