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Effect of Continuous Positive Airway Pressure (CPAP) and Cardiopulmonary Exercise Testing(CPET) in Patient With Obstructive Sleep Apnea (OSA) and Chronic Obstructive Pulmonary Disease (COPD)

This study has been completed.
Information provided by (Responsible Party):
University of Oklahoma Identifier:
First received: December 15, 2009
Last updated: May 19, 2014
Last verified: May 2014
Nasal CPAP will improve cardiopulmonary exercise test (CPET) performance in patients with overlap syndrome(COPD and OSA). Nasal CPAP is proven to improve cardiopulmonary exercise testing in patients with OSA. The investigators hypothesis is that patients with overlap syndrome will have a greater improvement in their cardiopulmonary exercise testing besides a possible improvement in their lung function test and airway resistance.

Condition Intervention
Obstructive Sleep Apnea
Chronic Obstructive Pulmonary Disease
Device: CPAP

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Effect of Nasal CPAP on Cardiopulmonary Exercise Testing in Patients With Overlap Syndrome

Resource links provided by NLM:

Further study details as provided by University of Oklahoma:

Primary Outcome Measures:
  • Efficacy of nasal CPAP on CPET performance in patients with overlap syndrome [ Time Frame: 2 years ]

Enrollment: 12
Study Start Date: June 2009
Study Completion Date: February 2014
Primary Completion Date: February 2014 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
CPET will be done on patients with overlap syndrome before and after CPAP treatment

Detailed Description:
Patients will be included if they have overlap syndrome. Patients will undergo a spirometry and CPET before being started on CPAP. Those tests will be repeated after 8-12 weeks of CPAP use. Patients will be excluded if they have any contraindication to mild exercise or they can't perform an exercise test due to limited mobility.

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Obstructive sleep apnea (OSA)
  • COPD

Exclusion Criteria:

  • Inability to perform exercise test due to musculoskeletal limitation
  • Cardiac condition preventing patient from mild exercise
  • Continuous oxygen supplement
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Please refer to this study by its identifier: NCT01033266

United States, Oklahoma
OU Medical Center
Oklahoma City, Oklahoma, United States, 73104
VA Medical Center
Oklahoma City, Oklahoma, United States, 73104
Sponsors and Collaborators
University of Oklahoma
Principal Investigator: Gary Kinasewitz, MD University of Oklahoma
Principal Investigator: Houssein Youness, MD University of Oklahoma
  More Information

Responsible Party: University of Oklahoma Identifier: NCT01033266     History of Changes
Other Study ID Numbers: 14587
Study First Received: December 15, 2009
Last Updated: May 19, 2014

Additional relevant MeSH terms:
Lung Diseases
Lung Diseases, Obstructive
Pulmonary Disease, Chronic Obstructive
Sleep Apnea Syndromes
Sleep Apnea, Obstructive
Respiratory Tract Diseases
Respiration Disorders
Sleep Disorders, Intrinsic
Sleep Wake Disorders
Nervous System Diseases processed this record on April 27, 2017