Effect of Continuous Positive Airway Pressure (CPAP) and Cardiopulmonary Exercise Testing(CPET) in Patient With Obstructive Sleep Apnea (OSA) and Chronic Obstructive Pulmonary Disease (COPD)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01033266
Recruitment Status : Completed
First Posted : December 16, 2009
Last Update Posted : May 20, 2014
Information provided by (Responsible Party):
University of Oklahoma

Brief Summary:
Nasal CPAP will improve cardiopulmonary exercise test (CPET) performance in patients with overlap syndrome(COPD and OSA). Nasal CPAP is proven to improve cardiopulmonary exercise testing in patients with OSA. The investigators hypothesis is that patients with overlap syndrome will have a greater improvement in their cardiopulmonary exercise testing besides a possible improvement in their lung function test and airway resistance.

Condition or disease Intervention/treatment Phase
Obstructive Sleep Apnea Chronic Obstructive Pulmonary Disease Device: CPAP Not Applicable

Detailed Description:
Patients will be included if they have overlap syndrome. Patients will undergo a spirometry and CPET before being started on CPAP. Those tests will be repeated after 8-12 weeks of CPAP use. Patients will be excluded if they have any contraindication to mild exercise or they can't perform an exercise test due to limited mobility.

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 12 participants
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Effect of Nasal CPAP on Cardiopulmonary Exercise Testing in Patients With Overlap Syndrome
Study Start Date : June 2009
Actual Primary Completion Date : February 2014
Actual Study Completion Date : February 2014

Resource links provided by the National Library of Medicine

Arm Intervention/treatment
CPET will be done on patients with overlap syndrome before and after CPAP treatment

Primary Outcome Measures :
  1. Efficacy of nasal CPAP on CPET performance in patients with overlap syndrome [ Time Frame: 2 years ]

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Obstructive sleep apnea (OSA)
  • COPD

Exclusion Criteria:

  • Inability to perform exercise test due to musculoskeletal limitation
  • Cardiac condition preventing patient from mild exercise
  • Continuous oxygen supplement

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01033266

United States, Oklahoma
OU Medical Center
Oklahoma City, Oklahoma, United States, 73104
VA Medical Center
Oklahoma City, Oklahoma, United States, 73104
Sponsors and Collaborators
University of Oklahoma
Principal Investigator: Gary Kinasewitz, MD University of Oklahoma
Principal Investigator: Houssein Youness, MD University of Oklahoma

Responsible Party: University of Oklahoma Identifier: NCT01033266     History of Changes
Other Study ID Numbers: 14587
First Posted: December 16, 2009    Key Record Dates
Last Update Posted: May 20, 2014
Last Verified: May 2014

Additional relevant MeSH terms:
Lung Diseases
Lung Diseases, Obstructive
Sleep Apnea Syndromes
Pulmonary Disease, Chronic Obstructive
Sleep Apnea, Obstructive
Respiratory Tract Diseases
Respiration Disorders
Sleep Disorders, Intrinsic
Sleep Wake Disorders
Nervous System Diseases