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Photodynamic Therapy Alone Versus Combined With Intravitreal Bevacizumab for Age-related Macular Degeneration

This study has been completed.
Information provided by (Responsible Party):
Takahiro Kawaji, Kumamoto University Identifier:
First received: December 12, 2009
Last updated: February 25, 2016
Last verified: February 2016
The purpose of this study is to compare 12-month results of two single initial treatments—photodynamic therapy with verteporfin alone and this therapy combined with intravitreal bevacizumab—for neovascular age-related macular degeneration, not including patients with polypoidal choroidal vasculopathy who were presumed to have age-related macular degeneration.

Condition Intervention
Age-related Macular Degeneration Drug: Bevacizumab

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Verteporfin Photodynamic Therapy Alone Versus Combined With Intravitreal Bevacizumab for Neovascular Age-related Macular Degeneration

Resource links provided by NLM:

Further study details as provided by Takahiro Kawaji, Kumamoto University:

Primary Outcome Measures:
  • Visual acuity [ Time Frame: The comparison between baseline and 12-month ]

Enrollment: 45
Study Start Date: October 2006
Study Completion Date: May 2008
Primary Completion Date: May 2008 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Bevacizumab Drug: Bevacizumab
A single intravitreal injection of 1.25 mg of bevacizumab (0.05 mL of solution prepared from Avastin, 100 mg/4 mL vial) was performed within 2 weeks after PDT treatment.
Other Name: Avastin


Ages Eligible for Study:   50 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • choroidal neovascularization caused by age-related macula degeneration
  • no previous treatment
  • a follow-up at least 12 months
  • a baseline visual acuity ranging from a letter score of 0 to 70 on the Early Treatment Diabetic Retinopathy Study chart

Exclusion Criteria:

  • choroidal neovascularization caused by other eye diseases
  • ocular surgery within the past 3 mouths
  • history of uveitis
  • intraocular pressure higher than 25 mmHg, or glaucoma
  • history of systemic or ocular thromboembolic events.
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Please refer to this study by its identifier: NCT01032109

Department of Ophthalmology and Visual Science, Graduate School of Medical Sciences, Kumamoto University
Kumamoto, Japan, 860-8556
Sponsors and Collaborators
Kumamoto University
Principal Investigator: Takahiro Kawaji, MD, PhD Department of Ophthalmology, Kumamoto University Graduate School & Medical Sciences
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Takahiro Kawaji, Associate Professor, Kumamoto University Identifier: NCT01032109     History of Changes
Other Study ID Numbers: PCBK610
Study First Received: December 12, 2009
Last Updated: February 25, 2016

Additional relevant MeSH terms:
Macular Degeneration
Retinal Degeneration
Retinal Diseases
Eye Diseases
Angiogenesis Inhibitors
Angiogenesis Modulating Agents
Growth Substances
Physiological Effects of Drugs
Growth Inhibitors
Antineoplastic Agents processed this record on August 17, 2017