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Effect of Turmeric on Diabetic Nephropathy

This study has been completed.
Shiraz University of Medical Sciences
Information provided by:
Shaheed Faghihi Hospital Identifier:
First received: November 16, 2009
Last updated: November 17, 2009
Last verified: November 2009
The purpose of this study is to investigate whether turmeric is effective in improvement of diabetic nephropathy and in decrease in the amount of proteinuria and cytokine levels.

Condition Intervention
Diabetic Nephropathy
Drug: Turmeric extract
Drug: Angiotensin-converting enzyme (ACE) inhibitor + Angiotensin-II type 1 receptor (ATI) blocker

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double Blind (Participant, Investigator)
Primary Purpose: Treatment

Resource links provided by NLM:

Further study details as provided by Shaheed Faghihi Hospital:

Enrollment: 50
Study Start Date: March 2008
Study Completion Date: August 2009
Primary Completion Date: June 2009 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: Turmeric

diabetic nephropathy patient

more than 300 mg/proteinuria

Drug: Turmeric extract
turmeric 500 mg TID for 45 days
Other Name: turmeric
Active Comparator: ACE inhibitor + ATI blocker

diabetic nephropathy

more than 300 mg/day proteinuria

Drug: Turmeric extract
turmeric 500 mg TID for 45 days
Other Name: turmeric
Drug: Angiotensin-converting enzyme (ACE) inhibitor + Angiotensin-II type 1 receptor (ATI) blocker
maximum dosage as patient tolerated for 45 days
Other Names:
  • enalapril
  • losartan

Detailed Description:
Diabetic nephropathy is leading cause of ESRF that many therapy recommended for it. In this study, we investigate effect of turmeric on diabetic nephropathy, thus we selected diabetic nephropathy patients and divided them into 2 groups. One group received turmeric + ACE inhibitor + Angiotensin II receptor blocker (ARB) and the second group received only ACE inhibitor + ARB.

Ages Eligible for Study:   18 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • diabetic nephropathy
  • more than 300 mg proteinuria/day
  • age more than 18 years old

Exclusion Criteria:

  • DM type 1
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Please refer to this study by its identifier: NCT01015937

Iran, Islamic Republic of
Shiraz, Fars, Iran, Islamic Republic of, 098
Sponsors and Collaborators
Shaheed Faghihi Hospital
Shiraz University of Medical Sciences
Principal Investigator: maryam pakfetrat, assistant professor Shiraz nephro-urology research center
  More Information

Additional Information:
Responsible Party: Office of Vice Chancellor for research in Shiraz UMS, Shiraz University of Medical Science Identifier: NCT01015937     History of Changes
Other Study ID Numbers: 3997
Study First Received: November 16, 2009
Last Updated: November 17, 2009

Keywords provided by Shaheed Faghihi Hospital:
serum IL8
serum TGFb
urinary IL8
urine TGFb

Additional relevant MeSH terms:
Kidney Diseases
Diabetic Nephropathies
Urologic Diseases
Urination Disorders
Urological Manifestations
Signs and Symptoms
Diabetes Complications
Diabetes Mellitus
Endocrine System Diseases
Angiotensin II
Turmeric extract
Angiotensin-Converting Enzyme Inhibitors
Vasoconstrictor Agents
Serine Proteinase Inhibitors
Protease Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Protective Agents
Physiological Effects of Drugs processed this record on May 22, 2017