Markers of Liver Apoptosis After Anesthesia With Sevoflurane or Propofol
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|ClinicalTrials.gov Identifier: NCT01000337|
Recruitment Status : Completed
First Posted : October 23, 2009
Results First Posted : September 11, 2012
Last Update Posted : May 19, 2017
|Condition or disease||Intervention/treatment||Phase|
|Liver Dysfunction||Drug: Sevoflurane Drug: Propofol||Not Applicable|
Female patients undergoing mastectomy or thyroidectomy under sevoflurane or propofol anesthesia will be recruited for the study. The type of anesthesia will be determined in a random way using a computer generated table.
All patients will be preoxygenated for 3 minutes before induction of anesthesia. Patients assigned to the sevoflurane group will receive an inhalation induction with sevoflurane via a primed anesthetic circle system and anesthesia will be maintained with sevoflurane. In the propofol group patients anaesthesia will be induced and maintained with propofol.
Blood samples for liver apoptotic markers will be collected before induction of anesthesia, after skin closure as well as 24 and 48 hours postoperatively.
Blood samples will be centrifuged, stored at -80 degrees Celsius and analyzed for M30 and M60 values with radioimmunoassay technique. Serum glutamic pyruvic transaminase (SGPT) and serum glutamic oxaloacetic transaminase (SGOT) levels will also be determined.
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||67 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||Single (Outcomes Assessor)|
|Official Title:||The Impact of Sevoflurane and Propofol Anesthesia on Hepatic Apoptosis Markers|
|Study Start Date :||October 2009|
|Actual Primary Completion Date :||November 2011|
|Actual Study Completion Date :||April 2012|
Active Comparator: sevoflurane
Sevoflurane concentration for induction of anesthesia 7-8%, for maintenance of anesthesia 2%.
Other Name: Sevorane, 2802252901023,
Active Comparator: Propofol
Propofol to induce anesthesia 2.5 mg/kg, for maintenance of anesthesia 6 mg/kg/h
Other Name: Lipuro, 2802467102017
- Changes in the M30 and M65 Markers Related to the Anesthesia Type [ Time Frame: preoperatively, end of surgery, 24 and 48 hours postoperatively ]Blood samples for determination of the markers M30 and M65 as well as the serum transaminases were collected preoperatively, at the end of surgery, 24 and 48 hours postoperatively.
- Transaminases [ Time Frame: February 2011 ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01000337
|Aretaieio Hospital, University of Athens|
|Athens, Attiki, Greece, 11528|
|Study Chair:||Argyro Fassoulaki, MD,PhD,DEAA||Chairman Department of Anesthesiology, Aretaieio Hospital|