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Energy Expenditure Responses to Acute Exercise in Older Women (Calorie Expenditure and Exercise) (CEE)

This study has been completed.
National Institute on Aging (NIA)
Information provided by (Responsible Party):
Washington University School of Medicine Identifier:
First received: October 1, 2009
Last updated: December 2, 2011
Last verified: December 2011

In older, normal-weight women (60-75 yrs, BMI=18-28 kg/m2), an acute bout of higher-intensity (60% of maximum effort) aerobic exercise, in comparison to an isocaloric bout of lower-intensity (45% of maximum effort) exercise (caloric expenditure of 3.5 kcal/kg body weight for both), will result in differential:

  1. decline in non-exercise activity calorie expenditure in the subsequent 48 hours after exercise;
  2. increase in resting metabolic rate 48 hours after exercise;
  3. increase in serum free triiodo-L-thyronine (free T3) concentrations immediately following exercise;
  4. decline from pre-exercise in plasma leptin and serum free T3 concentrations 48 hours after exercise.

Condition Intervention
Other: exercise

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Open Label
Official Title: Energy Expenditure Responses to Acute Exercise in Older Women

Resource links provided by NLM:

Further study details as provided by Washington University School of Medicine:

Primary Outcome Measures:
  • non-exercise activity calorie expenditure [ Time Frame: 2 days after exercise sessions ]

Secondary Outcome Measures:
  • resting metabolic rate [ Time Frame: 2 days after exercise sessions ]

Enrollment: 26
Study Start Date: October 2009
Study Completion Date: December 2011
Primary Completion Date: December 2011 (Final data collection date for primary outcome measure)
Intervention Details:
    Other: exercise
    exercise sessions at 45% and 60% of maximum effort

Ages Eligible for Study:   60 Years to 75 Years   (Adult, Senior)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  1. Women
  2. Age 60-75 years
  3. normal weight
  4. Weight-stable (± 5%) within the previous 3 months
  5. Non-smoking for last year
  6. Able to provide own transportation to study visits
  7. Not currently involved in any other research study
  8. Willing and able to participate in all aspects of the trial including research testing
  9. Willing to give informed consent to participate

Exclusion Criteria:

  1. Self-reported significant cardiovascular disease
  2. Other self-reported medical conditions such as diabetes, chronic or recurrent respiratory conditions, active cancer, musculoskeletal disease
  3. Medications known to affect exercise performance or metabolism
  4. Excess caffeine use (> 500mg/day)
  5. Any self-reported contraindications to exercise
  6. Clinical depression
  7. Abnormal cognitive function -
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Please refer to this study by its identifier: NCT00988299

United States, Missouri
Washington University School of Medicine
St. Louis, Missouri, United States, 63110
Sponsors and Collaborators
Washington University School of Medicine
National Institute on Aging (NIA)
Principal Investigator: Xuewen Wang, PhD Washington University School of Medicine
  More Information

Responsible Party: Washington University School of Medicine Identifier: NCT00988299     History of Changes
Other Study ID Numbers: 09-0864
K99AG031297 ( US NIH Grant/Contract Award Number )
Study First Received: October 1, 2009
Last Updated: December 2, 2011

Keywords provided by Washington University School of Medicine:
energy expenditure processed this record on May 25, 2017