Microparticles in Pediatric Inflammatory Disease
The purpose of this study is to provide data correlating levels of microparticles that circulate in the blood and disease activity in children with inflammatory bowel disease (IBD). The hypothesis is that circulating microparticles will be higher in children with active IBD, show inflammatory activity, and will be low in patients in remission as well as in healthy controls.
|Study Design:||Observational Model: Case Control
Time Perspective: Cross-Sectional
|Official Title:||Microparticles in Pediatric Inflammatory Bowel Disease|
|Study Start Date:||August 2009|
|Study Completion Date:||May 2011|
|Primary Completion Date:||May 2011 (Final data collection date for primary outcome measure)|
Once the response of microparticles to inflammation is defined in this patient population, the microparticles can be used as biomarkers of disease activity and could potentially use microparticles as targets of therapeutic agents.
This cross sectional study will enroll 15 Crohn's patients (5 inactive, 5 mild, 5 moderate-severe disease based on the pediatric Crohn's disease activity index), 15 Ulcerative Colitis patients (5 inactive, 5 mild, 5 moderate-severe disease based on the pediatric ulcerative colitis activity index), and 10 healthy controls.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00979485
|United States, Indiana|
|Indiana Unversity, Riley Hospital for Children|
|Indianapolis, Indiana, United States, 46202|
|Principal Investigator:||Steven ` Steiner, MD||Indiana University|