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Sirtuin Mediated Effects of 36 Hour Fast and 1 Hour Exercise

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified June 2012 by University of Aarhus.
Recruitment status was:  Active, not recruiting
Sponsor:
ClinicalTrials.gov Identifier:
NCT00978640
First Posted: September 17, 2009
Last Update Posted: June 20, 2012
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
University of Aarhus
  Purpose

Hypothesis: during fasting and exercise will there be an activation of sirtuins (Sirt1).

Primarily the investigators will investigate Sirt1 activity in muscle- and fat-biopsies after fasting for 36 hours and after 1 hour of ergometer-cycling at 50 Vo2max.

In addition to this the investigators will investigate the effect of fasting and exercise on the velocity of carbamide synthesis, aminoacid rate of turnover and glucose rate of turnover.


Condition Intervention
Healthy Other: fast and exercise Other: exercise

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Official Title: Sirtuin Mediated Effects of 36 h Fast and 1 h Exercise

Resource links provided by NLM:


Further study details as provided by University of Aarhus:

Primary Outcome Measures:
  • Sirt1 activity [ Time Frame: 60 min ]

Secondary Outcome Measures:
  • secondary will we investigate the effect of fasting and exercise on the velocity of carbamide synthesis, aminoacid rate of turnover and glucose rate of turnover. [ Time Frame: 4 h ]

Estimated Enrollment: 8
Study Start Date: September 2009
Estimated Study Completion Date: June 2012
Estimated Primary Completion Date: June 2012 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: fasting and exercise
36 h fast and 1 h ergometer cycling 50% VO2max
Other: fast and exercise
fasting 36 h and exercise 1 h 50% VO2max
Experimental: exercise
1 h ergometer cycling 50% VO2max
Other: exercise
exercise 1 h 50% VO2max

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 45 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • healthy men
  • Body mass index (BMI) 20-26
  • age 18-45 years

Exclusion Criteria:

  • any kind of disease
  • any use of medicine
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00978640


Locations
Denmark
mikkel Holm Vendelbo
Århus, Jylland, Denmark, 8000
Sponsors and Collaborators
University of Aarhus
  More Information

Responsible Party: University of Aarhus
ClinicalTrials.gov Identifier: NCT00978640     History of Changes
Other Study ID Numbers: 07.09.2009
First Submitted: September 16, 2009
First Posted: September 17, 2009
Last Update Posted: June 20, 2012
Last Verified: June 2012

Keywords provided by University of Aarhus:
Sirt1 activity