Etiology, Epidemiology and Prognostics of Acute Kidney Injury (AKI)
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ClinicalTrials.gov Identifier: NCT00953992
Recruitment Status :
First Posted : August 6, 2009
Last Update Posted : August 22, 2019
Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
To investigate the etiology, epidemiology and prognostic factors of acute kidney injury.
To find out risk factors that relate with the prognosis of acute kidney injury,focusing on inflammation, oxidative stress and nutritional status.
To study on the relationship between gene polymorphism and prognosis of acute kidney injury.
Condition or disease
Renal FailureNutrition Disorders
to investigate the relationship between preexisting malnutrition and adverse outcomes in patients with AKI
- Several nutritional assessment methods such as anthropometric, clinical and biochemical evaluations have been used; however, no single indicator is considered to be a "gold standard."
to evaluate the association of serum nutritional variables and prognosis of acute kidney injury
Given the different half-lives of serum nutritional markers, we hypothesized that the utility of serum nutritional variables as prognostic predictors may differ in early death (<7 days) and late death (>7 days, <28 days) patients.
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Layout table for eligibility information
Ages Eligible for Study:
16 Years to 88 Years (Child, Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Patients selected from a university-affiliated hospital in Shanghai, China.
age >=16 years and <= 88 years
clinically diagnosed with acute kidney injury, according RIFLE or KDIGO criteria.
acute Renal Failure occurring in the setting of burns, obstructive uropathy, allergic interstitial nephritis, acute or rapidly progressive glomerulonephritis, vasculitis, hemolytic-uremic syndrome, thrombotic thrombocytopenic purpura (TTP), malignant hypertension, scleroderma renal crisis, atheroembolism, functional or surgical nephrectomy, hepatorenal syndrome, cyclosporin or tacrolimus nephrotoxicity
Do Not Resuscitate (DNR) status
subjects enrolled in another clinical trial that could affect the outcome of this study protocol