We're building a better ClinicalTrials.gov. Check it out and tell us what you think!
ClinicalTrials.gov Menu

The Effect of Kiwi on Blood Pressure, Endothelial Function, Antioxidant Capacity and Gene Expression

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT00948363
Recruitment Status : Completed
First Posted : July 29, 2009
Last Update Posted : June 29, 2017
University of Oslo
Information provided by (Responsible Party):
Tor Ole Klemsdal, Oslo University Hospital

Brief Summary:
The purpose of this study is to determine whether the intake of kiwi fruits will reduce systolic and diastolic blood pressure compared to intake of apples. The investigators hypothesize that the increased intake lutein or other components in the kiwi fruit will enhance nitric oxide bioavailability and lead to vascular relaxation.

Condition or disease Intervention/treatment Phase
Hypertension Other: Kiwi fruits Other: Apple Not Applicable

Detailed Description:
An interesting finding in the Oslo Antioxidant Study was that intake of 3 kiwi fruits reduced blood pressure in a clinical significant manner compared to controls. The mechanism for the blood pressure reducing effect of kiwi or the responsible components are not elucidated. However, plasma lutein levels and antioxidant capacity measured by the ferric reducing antioxidant power was increased in the kiwi group. Moreover, gene expression was also altered by the increased intake of kiwi.

Layout table for study information
Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 118 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary Purpose: Treatment
Official Title: The Effect of Kiwi on Blood Pressure, Endothelial Function, Antioxidant Capacity and Gene Expression in Mildly Hypertensive Subjects
Study Start Date : August 2009
Actual Primary Completion Date : December 2010
Actual Study Completion Date : December 2010

Resource links provided by the National Library of Medicine

Arm Intervention/treatment
Active Comparator: Kiwi fruits Other: Kiwi fruits
Daily intake of 3 kiwi fruits for 8 weeks

Placebo Comparator: Apple Other: Apple
Daily intake of 1 apple (equivalent in energy) for 8 weeks

Primary Outcome Measures :
  1. Blood pressure [ Time Frame: 8 weeks ]

Secondary Outcome Measures :
  1. Endothelial function [ Time Frame: 8 weeks ]

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Layout table for eligibility information
Ages Eligible for Study:   35 Years to 69 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Systolic blood pressure 130-159 mmHg
  • Diastolic blood pressure 85-99 mmHg
  • Body mass index <35 kg/m2

Exclusion Criteria:

  • Systolic blood pressure >160 mmHg or <129 mmHg
  • Diastolic blood pressure >100 mmHg or <84 mmHg
  • Current use or need for blood pressure lowering medication
  • Symptomatic cardiovascular disease, diabetes, renal dysfunction, psychiatric disorder, pregnancy or lactation, history of obesity surgery.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00948363

Layout table for location information
Department of Preventive Cardiology
Oslo, Norway, 0407
Oslo University Hospital
Oslo, Norway, 0407
Sponsors and Collaborators
Oslo University Hospital
University of Oslo
Layout table for investigator information
Principal Investigator: Serena Tonstad, Professor Preventive Cardiology, Oslo University Hospital
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Layout table for additonal information
Responsible Party: Tor Ole Klemsdal, Chief Consultant, Oslo University Hospital
ClinicalTrials.gov Identifier: NCT00948363    
Other Study ID Numbers: 1335
First Posted: July 29, 2009    Key Record Dates
Last Update Posted: June 29, 2017
Last Verified: June 2017
Keywords provided by Tor Ole Klemsdal, Oslo University Hospital:
Kiwi fruits
Blood pressure
Endothelial function
Antioxidant capacity
Additional relevant MeSH terms:
Layout table for MeSH terms
Vascular Diseases
Cardiovascular Diseases