Oxygen Concentration Should be Kept at the Lowest Possible Level During Recruitment

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00944086
Recruitment Status : Completed
First Posted : July 22, 2009
Last Update Posted : August 6, 2009
Information provided by:
Istanbul University

Brief Summary:
In This Study, Our Goal is to Compare the Effects of Recruitment Manoeuvre Which is Applied With Different Oxygen Concentrations on Oxygenation and Respiratory Mechanics During Pneumoperitoneum

Condition or disease Intervention/treatment
Laparoscopic Surgery Other: Recruitment Manoeuvre

Detailed Description:

Detailed Description:

"Recruitment manoeuvre" which has been defined and become popular in the recent years is nowadays widely accepted and applied. The positive effects of the recruitment manoeuvre during and after surgery on respiratory mechanics and oxygenation have been reported. The duration and the applied pressure values of recruitment manoeuvre have been defined well and in detail regarding the definitions for this manoeuvre (1-3). Despite these definitions, no detailed information has been provided on the effects of the oxygen and oxygen concentration during recruitment manoeuvre .

Atelectasis develops after the induction of anaesthesia, even in healthy subjects, and is associated with an increase in intraoperative shunt leading to impairment of gas exchange (4). It is well known that in patients, who have undergone mechanical ventilation with high oxygen concentration levels, oxygen replaces the less insoluble nitrogen. Partial oxygen pressure increases with the implementation of oxygen in high concentrations, and the oxygen flow into the blood increases. But when the gas flow into the blood is more than inspired, absorption atelectasis develops in lungs - due to appliance of high oxygen concentration. Atelectasis may also develop due to different reasons such as failure in secretion clearance during the surgery, replacement of nitrogen with inhalation anaesthetics and appliance of pneumoperitoneum.

In the recent years, many studies have analyzed the effects of recruitment manoeuvre during pneumoperitoneum and laparoscopic surgery on respiratory mechanics and oxygenation, and reported the benefits of recruitment in these operations (4-6).

In this study, our goal is to compare the effects of recruitment manoeuvre which is applied with different oxygen concentrations on oxygenation and respiratory mechanics during pneumoperitoneum.

Study Type : Observational
Observational Model: Case-Only
Time Perspective: Prospective
Official Title: A Prospective Randomized Clinical Study:Oxygen Concentration Should be Kept at the Lowest Possible Level During Recruitment Manoeuvres
Study Start Date : May 2008
Actual Primary Completion Date : August 2008
Actual Study Completion Date : August 2008

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Oxygen Therapy
U.S. FDA Resources

Group/Cohort Intervention/treatment
Recruitment Manoeuvre ,Laparoscopy Other: Recruitment Manoeuvre
Recruitment Manoeuvre

Information from the National Library of Medicine

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Ages Eligible for Study:   27 Years to 61 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
This study has been applied on 32 cases which have undergone laparoscopic cholecystectomy.

Exclusion Criteria:

  • Patients, who were older than 65 years,
  • had respiratory system and cardiovascular diseases,
  • used medication that could affect the respiratory function or smokers have been excluded.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00944086

Cerrahpasa School of Medicine
Istanbul, Turkey
Sponsors and Collaborators
Istanbul University Identifier: NCT00944086     History of Changes
Other Study ID Numbers: Akaratas
First Posted: July 22, 2009    Key Record Dates
Last Update Posted: August 6, 2009
Last Verified: August 2009

Keywords provided by Istanbul University:
Oxygen Concentration