Natriuretic Peptides - Predictors of In-hospital and Long-term Major Adverse Cardiac Events After Emergency Surgery?

This study has been completed.
Information provided by (Responsible Party):
Medical University of Graz Identifier:
First received: July 18, 2009
Last updated: June 9, 2015
Last verified: June 2015
The investigators hypothesize that the level of perioperative natriuretic peptides is associated with in-hospital and long term major adverse cardiac events.


Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Prospective Study to Evaluate the Predictive Value of Brain Natriuretic Peptides for Adverse Long-term Cardiac Outcome

Further study details as provided by Medical University of Graz:

Primary Outcome Measures:
  • Occurence of Adverse Cardiac Events [ Time Frame: postoperatively (index surgery) until a median follow-up of 34 months ] [ Designated as safety issue: Yes ]

    Occurence of major adverse cardiac events (composite of nonfatal myocardial infarction, acute heart failure or death).

    Non-fatal Myocardial infarction was defined as a typical increase and decrease of troponin together with evidence of myocardial ischemia with at least one of the following: symptoms of ischemia, ECG changes indicative of ischemia or new Q waves, or imaging evidence of new regional wall motion abnormality.

    Acute heart failure was defined as clinical signs and symptoms of heart failure with echocardiographic evidence of cardiac dysfunction and clinical response to treatment directed towards heart failure.

Other Outcome Measures:
  • NT-ProBNP Preoperative [ Time Frame: 0-24 hours before induction of anesthesia ] [ Designated as safety issue: No ]
    NT-ProBNP was measured 0-24 hours before induction of anesthesia

  • Association Between Preoperative NT-ProBNP and Occurence of Adverse Cardiac Events [ Time Frame: postoperatively (index surgery) until a median follow-up of 34 months ] [ Designated as safety issue: No ]
    Evaluation of the association between preoperative NT-ProBNP and occurence of adverse cardiac events

Biospecimen Retention:   Samples Without DNA
one vial of serum per patient is retained

Enrollment: 297
Study Start Date: February 2008
Study Completion Date: February 2014
Primary Completion Date: January 2014 (Final data collection date for primary outcome measure)
No treatment
Consecutive patients undergoing emergency surgery

Detailed Description:
The purpose of the study is to measure levels of brain natriuretic peptides before and after urgent non-cardiac surgery and to evaluate their predictive value for adverse long-term outcome.

Ages Eligible for Study:   50 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Consecutive patients undergoing emergency non-cardiac surgery

Inclusion criteria:

  • Emergency surgery:

    1. Vascular
    2. Intra-abdominal
    3. Orthopedic

      Exclusion Criteria:

  • Patients unable to provide informed consent
  • Thoracic surgery
  • Trauma surgery
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00942786

Department of Anesthesia and Intensive Care Medicine
Graz, Austria, 8036
Sponsors and Collaborators
Medical University of Graz
Principal Investigator: Elisabeth Mahla, M.D. Department of Anesthesiology and Intensive Care Medicine, Medical University of Graz
  More Information

No publications provided

Responsible Party: Medical University of Graz Identifier: NCT00942786     History of Changes
Other Study ID Numbers: 19-077 ex 07/08
Study First Received: July 18, 2009
Results First Received: January 26, 2015
Last Updated: June 9, 2015
Health Authority: Austria: Ethikkommission

Keywords provided by Medical University of Graz:
natriuretic peptides
emergency non-cardiac surgery processed this record on November 27, 2015