Natriuretic Peptides - Predictors of In-hospital and Long-term Major Adverse Cardiac Events After Emergency Surgery?
The investigators hypothesize that the level of perioperative natriuretic peptides is associated with in-hospital and long term major adverse cardiac events.
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Prospective Study to Evaluate the Predictive Value of Brain Natriuretic Peptides for Adverse Long-term Cardiac Outcome|
- Occurence of Adverse Cardiac Events [ Time Frame: postoperatively (index surgery) until a median follow-up of 34 months ] [ Designated as safety issue: Yes ]
Occurence of major adverse cardiac events (composite of nonfatal myocardial infarction, acute heart failure or death).
Non-fatal Myocardial infarction was defined as a typical increase and decrease of troponin together with evidence of myocardial ischemia with at least one of the following: symptoms of ischemia, ECG changes indicative of ischemia or new Q waves, or imaging evidence of new regional wall motion abnormality.
Acute heart failure was defined as clinical signs and symptoms of heart failure with echocardiographic evidence of cardiac dysfunction and clinical response to treatment directed towards heart failure.
- NT-ProBNP Preoperative [ Time Frame: 0-24 hours before induction of anesthesia ] [ Designated as safety issue: No ]NT-ProBNP was measured 0-24 hours before induction of anesthesia
- Association Between Preoperative NT-ProBNP and Occurence of Adverse Cardiac Events [ Time Frame: postoperatively (index surgery) until a median follow-up of 34 months ] [ Designated as safety issue: No ]Evaluation of the association between preoperative NT-ProBNP and occurence of adverse cardiac events
Biospecimen Retention: Samples Without DNA
one vial of serum per patient is retained
|Study Start Date:||February 2008|
|Study Completion Date:||February 2014|
|Primary Completion Date:||January 2014 (Final data collection date for primary outcome measure)|
Consecutive patients undergoing emergency surgery
The purpose of the study is to measure levels of brain natriuretic peptides before and after urgent non-cardiac surgery and to evaluate their predictive value for adverse long-term outcome.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00942786
|Department of Anesthesia and Intensive Care Medicine|
|Graz, Austria, 8036|
|Principal Investigator:||Elisabeth Mahla, M.D.||Department of Anesthesiology and Intensive Care Medicine, Medical University of Graz|