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Metabolic Fate Modifications of Saturated Fats After an Overfeeding (SURNUT)

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ClinicalTrials.gov Identifier: NCT00905892
Recruitment Status : Completed
First Posted : May 21, 2009
Last Update Posted : June 23, 2011
Sponsor:
Collaborator:
Institut National de la Santé Et de la Recherche Médicale, France
Information provided by:
Centre de Recherche en Nutrition Humaine Rhone-Alpe

Study Description
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Brief Summary:
The purpose of this study is to determine the partitioning of exogenous lipids in the postprandial period while a study of overfeeding. The method is based on the incorporation of a stable isotopic tracer (d31_palmitic acid, d31_C16) in lipoprotein triglycerides (TG-CHYLOMICRON and TG-VLDL) and in free fatty acids (FFA).

Condition or disease Intervention/treatment Phase
Obesity Lipid Metabolism Inflammation Dietary Supplement: Hyperlipidic overfeeding Not Applicable

Detailed Description:
Healthy overweight and lean young men are subjected to an overfeeding during 56 days which corresponds to a supplement of 761 Kcal/day. During two exploration days (before : D0 et after : D56 overfeeding) they have ingested a breakfast with tracer (d31_palmitic acid, d31_C16, 20mg/kg) and blood and urine samples were collected every hour of each exploration day. The enrichment in deuterium was measured by gas chromatography-organic mass spectrometry (GC-OMS) in palmitic acid pool of lipid fractions.

Study Design
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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 40 participants
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Official Title: Metabolic Fate Modifications of Saturated Fats After an Overfeeding
Study Start Date : September 2005
Actual Primary Completion Date : December 2009
Actual Study Completion Date : March 2010
Arms and Interventions
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Intervention Details:
  • Dietary Supplement: Hyperlipidic overfeeding
    100g per day of cheese + 40g per day of almonds + 20g per day of butter

Outcome Measures
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Primary Outcome Measures :
  1. Post prandial partitioning of exogenous lipids [ Time Frame: Before and after overfeeding ]

Secondary Outcome Measures :
  1. Genes expression in adipose and muscle tissues [ Time Frame: Before and after overfeeding ]

Eligibility Criteria
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Ages Eligible for Study:   18 Years to 55 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • 18 to 55 years old
  • BMI 18 to 30 kg/m²
  • Stable physical activity
  • Safety subject during medical consultation

Exclusion Criteria:

  • Medical or surgical history which may affect energy expenditure (renal -cardiovascular -hepatic- endocrine-inflammatory diseases)
  • Drug use that could affect energy expenditure (steroids, nicotine substitutes, thyroid hormones)
  • Eating disorder
  • Intensive sportive activity
  • Subjects who Smoke
  • Claustrophobic subjects
Contacts and Locations
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Information from the National Library of Medicine

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Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00905892


Locations
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France
Centre de recherche en nutrition humaine Rhone-Alpes
Pierre-Bénite, France, 69495
Sponsors and Collaborators
Centre de Recherche en Nutrition Humaine Rhone-Alpe
Institut National de la Santé Et de la Recherche Médicale, France
Investigators
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Study Director: Martine Laville, PhD, MD Centre de Recherche en Nutrition Humaine Rhône-Alpes
More Information
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Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):

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Responsible Party: Martine Laville PhD, MD, CRNHRA
ClinicalTrials.gov Identifier: NCT00905892     History of Changes
Other Study ID Numbers: CRNHRA-09-002
First Posted: May 21, 2009    Key Record Dates
Last Update Posted: June 23, 2011
Last Verified: June 2011
Keywords provided by Centre de Recherche en Nutrition Humaine Rhone-Alpe:
overfeeding
stable isotopes
lipoprotein metabolism
lipid oxidation
 fat distribution
gene expression
endotoxemia
mass spectrometry/gas chromatography
Additional relevant MeSH terms:
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Inflammation
Pathologic Processes