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Metabolic Fate Modifications of Saturated Fats After an Overfeeding (SURNUT)

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ClinicalTrials.gov Identifier: NCT00905892
Recruitment Status : Completed
First Posted : May 21, 2009
Last Update Posted : June 23, 2011
Sponsor:
Collaborator:
Institut National de la Santé Et de la Recherche Médicale, France
Information provided by:
Centre de Recherche en Nutrition Humaine Rhone-Alpe

Brief Summary:
The purpose of this study is to determine the partitioning of exogenous lipids in the postprandial period while a study of overfeeding. The method is based on the incorporation of a stable isotopic tracer (d31_palmitic acid, d31_C16) in lipoprotein triglycerides (TG-CHYLOMICRON and TG-VLDL) and in free fatty acids (FFA).

Condition or disease Intervention/treatment Phase
Obesity Lipid Metabolism Inflammation Dietary Supplement: Hyperlipidic overfeeding Not Applicable

Detailed Description:
Healthy overweight and lean young men are subjected to an overfeeding during 56 days which corresponds to a supplement of 761 Kcal/day. During two exploration days (before : D0 et after : D56 overfeeding) they have ingested a breakfast with tracer (d31_palmitic acid, d31_C16, 20mg/kg) and blood and urine samples were collected every hour of each exploration day. The enrichment in deuterium was measured by gas chromatography-organic mass spectrometry (GC-OMS) in palmitic acid pool of lipid fractions.

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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 40 participants
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Official Title: Metabolic Fate Modifications of Saturated Fats After an Overfeeding
Study Start Date : September 2005
Actual Primary Completion Date : December 2009
Actual Study Completion Date : March 2010

Intervention Details:
  • Dietary Supplement: Hyperlipidic overfeeding
    100g per day of cheese + 40g per day of almonds + 20g per day of butter


Primary Outcome Measures :
  1. Post prandial partitioning of exogenous lipids [ Time Frame: Before and after overfeeding ]

Secondary Outcome Measures :
  1. Genes expression in adipose and muscle tissues [ Time Frame: Before and after overfeeding ]


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Ages Eligible for Study:   18 Years to 55 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • 18 to 55 years old
  • BMI 18 to 30 kg/m²
  • Stable physical activity
  • Safety subject during medical consultation

Exclusion Criteria:

  • Medical or surgical history which may affect energy expenditure (renal -cardiovascular -hepatic- endocrine-inflammatory diseases)
  • Drug use that could affect energy expenditure (steroids, nicotine substitutes, thyroid hormones)
  • Eating disorder
  • Intensive sportive activity
  • Subjects who Smoke
  • Claustrophobic subjects

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00905892


Locations
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France
Centre de recherche en nutrition humaine Rhone-Alpes
Pierre-Bénite, France, 69495
Sponsors and Collaborators
Centre de Recherche en Nutrition Humaine Rhone-Alpe
Institut National de la Santé Et de la Recherche Médicale, France
Investigators
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Study Director: Martine Laville, PhD, MD Centre de Recherche en Nutrition Humaine Rhône-Alpes

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
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Responsible Party: Martine Laville PhD, MD, CRNHRA
ClinicalTrials.gov Identifier: NCT00905892     History of Changes
Other Study ID Numbers: CRNHRA-09-002
First Posted: May 21, 2009    Key Record Dates
Last Update Posted: June 23, 2011
Last Verified: June 2011
Keywords provided by Centre de Recherche en Nutrition Humaine Rhone-Alpe:
overfeeding
stable isotopes
lipoprotein metabolism
lipid oxidation
fat distribution
gene expression
endotoxemia
mass spectrometry/gas chromatography
Additional relevant MeSH terms:
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Inflammation
Pathologic Processes