Genetic Susceptibility for Bronchopulmonary Dysplasia in Preterm Infants (GENBPD)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00904774
Recruitment Status : Unknown
Verified May 2009 by Centre Hospitalier Intercommunal Creteil.
Recruitment status was:  Enrolling by invitation
First Posted : May 20, 2009
Last Update Posted : May 20, 2009
Information provided by:
Centre Hospitalier Intercommunal Creteil

Brief Summary:

Despite considerable obstetric and neonatal advances in the care of very low birth weight (VLBW) neonates, bronchopulmonary dysplasia (BPD) continues to occur among 20 to 40% of surviving infants, and new ways for combatting this disease must be found. BPD appears to result from arrested lung development, but its etiology has not yet been fully established. Besides the role of the exposure of the immature lung to injurious factors in the development of BPD, a genetic susceptibility for BPD in preterm infants was recently evidenced. Taking advantage of new genomic technologies, the objective of the investigators' project is to identify predisposing human genetic variants through:

  1. a genome-wide association (GWA) study in VLBW neonates,
  2. a candidate-gene association study, including selection of single nucleotide polymorphisms (SNPs) found in (a) and
  3. functional studies of any SNP found to be convincingly associated with BPD in (a) and (b).

Condition or disease
Bronchopulmonary Dysplasia

Study Type : Observational
Estimated Enrollment : 800 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Polymorphisms of Genes Controlling Alveolar Development and Risk of Bronchopulmonary Dysplasia
Study Start Date : May 2009

Resource links provided by the National Library of Medicine

premature neonates
gestational age less than 28 weeks

Primary Outcome Measures :
  1. bronchopulmonary dysplasia [ Time Frame: 36 weeks of postconceptional age ]

Information from the National Library of Medicine

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Ages Eligible for Study:   up to 8 Weeks   (Child)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Premature neonates

Inclusion Criteria:

  • Gestational age < 28 weeks
  • Inborn birth
  • Prophylactic administration of surfactant in the delivery room
  • Written informed consent obtained from parents

Exclusion Criteria:

  • Gestational age of 28 weeks or more
  • Outborn birth
  • No prophylactic administration of surfactant in the delivery room
  • Congenital malformation
  • Absence of written informed consent obtained from parents

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00904774

Centre Hospitalier Intercommunal
Creteil, France, 94000
Sponsors and Collaborators
Centre Hospitalier Intercommunal Creteil

Additional Information:
Responsible Party: Delacourt, Christophe, MD, PhD, INSERM U955 Identifier: NCT00904774     History of Changes
Other Study ID Numbers: AOR 07 018
First Posted: May 20, 2009    Key Record Dates
Last Update Posted: May 20, 2009
Last Verified: May 2009

Keywords provided by Centre Hospitalier Intercommunal Creteil:
bronchopulmonary dysplasia
lung development

Additional relevant MeSH terms:
Bronchopulmonary Dysplasia
Pathologic Processes
Ventilator-Induced Lung Injury
Lung Injury
Lung Diseases
Respiratory Tract Diseases
Infant, Premature, Diseases
Infant, Newborn, Diseases