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Predictors of Cord Blood Immunoglobin E (IgE) Levels

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified May 2009 by Min-Sheng General Hospital.
Recruitment status was:  Recruiting
Sponsor:
ClinicalTrials.gov Identifier:
NCT00902096
First Posted: May 14, 2009
Last Update Posted: May 14, 2009
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Min-Sheng General Hospital
  Purpose

Background: Increased total serum IgE levels are a common characteristic of atopic diseases. Increased cord blood IgE levels, in conjunction with a family history of atopy, are associated with the development of allergic diseases in children. However, little is known about predictors of cord blood IgE levels.

Objective: The aim of our study was to identify predictors of cord blood IgE levels in an ongoing large birth cohort of infants with or without a family history of atopy.

Methods: Blood sampling of mothers was performed just before the delivery of newborns. Cord blood was also collected when the child was born. Maternal and cord blood was measured for IgE levels and cytokines. Questionnaires were administered after birth of the infant.


Condition
Atopy

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective

Further study details as provided by Min-Sheng General Hospital:

Primary Outcome Measures:
  • cord blood IgE [ Time Frame: at birth ]

Secondary Outcome Measures:
  • Cord blood cytokines or other mediators [ Time Frame: at birth ]

Estimated Enrollment: 800
Study Start Date: April 2009
Groups/Cohorts
Prenatal factors
Prenatal factors to predict cord blood IgE

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
hospital and primary care clinic based study
Criteria

Inclusion Criteria:

  • Mothers in pregnancy 18 years of age or older, AND
  • Mothers able to speak Chinese.

Exclusion Criteria:

  • Infant delivered at less than 36 weeks' gestation,
  • Infant with Apgar score in 5 minutes after birth < 7,
  • Infant with a major congenital anomaly, OR
  • Infant admitted to an intensive care unit.
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00902096


Contacts
Contact: Chien-Han Chen, MD 886-3-3179599 ext 2004 chinsword@yahoo.com.tw

Locations
Taiwan
Min-Sheng General Hospital Recruiting
Taoyuan, Taiwan
Contact: Chien-Han Chen, MD       chinsword@yahoo.com.tw   
Principal Investigator: Chien-Han Chen, MD         
Sponsors and Collaborators
Min-Sheng General Hospital
Investigators
Principal Investigator: Chien-Han Chen, MD Min-Sheng General Hospital
  More Information

Responsible Party: Chien-Han Chen, Min-Sheng General Hospital
ClinicalTrials.gov Identifier: NCT00902096     History of Changes
Other Study ID Numbers: 2009008
First Submitted: May 13, 2009
First Posted: May 14, 2009
Last Update Posted: May 14, 2009
Last Verified: May 2009

Keywords provided by Min-Sheng General Hospital:
cord blood
IgE
prenatal
predictor