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Predictors of Cord Blood Immunoglobin E (IgE) Levels

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified May 2009 by Min-Sheng General Hospital.
Recruitment status was:  Recruiting
Information provided by:
Min-Sheng General Hospital Identifier:
First received: May 13, 2009
Last updated: NA
Last verified: May 2009
History: No changes posted

Background: Increased total serum IgE levels are a common characteristic of atopic diseases. Increased cord blood IgE levels, in conjunction with a family history of atopy, are associated with the development of allergic diseases in children. However, little is known about predictors of cord blood IgE levels.

Objective: The aim of our study was to identify predictors of cord blood IgE levels in an ongoing large birth cohort of infants with or without a family history of atopy.

Methods: Blood sampling of mothers was performed just before the delivery of newborns. Cord blood was also collected when the child was born. Maternal and cord blood was measured for IgE levels and cytokines. Questionnaires were administered after birth of the infant.


Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective

Further study details as provided by Min-Sheng General Hospital:

Primary Outcome Measures:
  • cord blood IgE [ Time Frame: at birth ]

Secondary Outcome Measures:
  • Cord blood cytokines or other mediators [ Time Frame: at birth ]

Estimated Enrollment: 800
Study Start Date: April 2009
Prenatal factors
Prenatal factors to predict cord blood IgE


Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
hospital and primary care clinic based study

Inclusion Criteria:

  • Mothers in pregnancy 18 years of age or older, AND
  • Mothers able to speak Chinese.

Exclusion Criteria:

  • Infant delivered at less than 36 weeks' gestation,
  • Infant with Apgar score in 5 minutes after birth < 7,
  • Infant with a major congenital anomaly, OR
  • Infant admitted to an intensive care unit.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00902096

Contact: Chien-Han Chen, MD 886-3-3179599 ext 2004

Min-Sheng General Hospital Recruiting
Taoyuan, Taiwan
Contact: Chien-Han Chen, MD   
Principal Investigator: Chien-Han Chen, MD         
Sponsors and Collaborators
Min-Sheng General Hospital
Principal Investigator: Chien-Han Chen, MD Min-Sheng General Hospital
  More Information

Responsible Party: Chien-Han Chen, Min-Sheng General Hospital Identifier: NCT00902096     History of Changes
Other Study ID Numbers: 2009008
Study First Received: May 13, 2009
Last Updated: May 13, 2009

Keywords provided by Min-Sheng General Hospital:
cord blood
predictor processed this record on September 21, 2017