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Study of a Polymorphism in Patients With Prostate Cancer

This study has been completed.
Information provided by:
National Cancer Institute (NCI) Identifier:
First received: May 9, 2009
Last updated: April 29, 2015
Last verified: February 2007

RATIONALE: Studying samples of blood from patients with cancer and from healthy participants in the laboratory may help doctors learn more about changes that may occur in DNA.

PURPOSE: This laboratory study is looking at blood samples from patients with prostate cancer and from healthy participants to identify a polymorphism that may help in the study of prostate cancer.

Condition Intervention
Prostate Cancer
Genetic: mutation analysis
Genetic: polymerase chain reaction
Genetic: polymorphism analysis

Study Type: Observational
Official Title: Retrospective Analysis of Endostatin Genotype in Prostate Cancer Patients to Assess the Association of a Single Nucleotide Polymorphism (D104N) in Endostatin and Prostate Cancer

Resource links provided by NLM:

Further study details as provided by National Cancer Institute (NCI):

Primary Outcome Measures:
  • Frequency of D104N COL18A1 polymorphism in patients with prostate cancer and in healthy participants

Secondary Outcome Measures:
  • Frequency of D104N COL18A1 polymorphism in African-American patients with prostate cancer and in healthy participants

Estimated Enrollment: 750
Detailed Description:



  • Determine the incidence of the D104N COL18A1 polymorphism in patients with prostate cancer.


  • Determine the incidence of this polymorphism in African-American patients with prostate cancer.

OUTLINE: This is a retrospective, multicenter study.

DNA is extracted from preexisting serum samples and polymerase chain reaction is performed to determine the genotype pattern.

PROJECTED ACCRUAL: A total of 500 patients and 250 healthy participants will be accrued for this study.


Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes


  • Diagnosis of prostate cancer OR healthy participant
  • Patient enrolled on an IRB-approved clinical trial at the National Cancer Institute or Northwestern University, including, but not limited to, any of the following:

    • NCI-99-C-0052
    • NCI-95-C-0178
    • NCI-00-C-003
    • NCI-00-C-0080


  • Not specified


  • Not specified
  Contacts and Locations
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Please refer to this study by its identifier: NCT00900185

Sponsors and Collaborators
National Cancer Institute (NCI)
Study Chair: William D. Figg, PharmD National Cancer Institute (NCI)
  More Information

Price DK, Macpherson GR, Dahut W, et al.: A mutation in COL18A1 and the association with prostate cancer. [Abstract] American Association for Cancer Research: 94th Annual Meeting, 11-14th July 2003, Washington, D.C. 44: A-4054, 810, 2003. Identifier: NCT00900185     History of Changes
Other Study ID Numbers: CDR0000304552
Study First Received: May 9, 2009
Last Updated: April 29, 2015

Keywords provided by National Cancer Institute (NCI):
recurrent prostate cancer
stage I prostate cancer
stage IIB prostate cancer
stage IIA prostate cancer
stage III prostate cancer
stage IV prostate cancer

Additional relevant MeSH terms:
Prostatic Neoplasms
Genital Neoplasms, Male
Urogenital Neoplasms
Neoplasms by Site
Genital Diseases, Male
Prostatic Diseases processed this record on May 25, 2017