Gene Expression Profiles in Predicting Survival of Patients With Head and Neck Cancer
|ClinicalTrials.gov Identifier: NCT00897052|
Recruitment Status : Completed
First Posted : May 12, 2009
Last Update Posted : September 10, 2012
RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors predict survival of patients with head and neck cancer.
PURPOSE: This laboratory study is assessing gene expression profiles in predicting survival of patients with head and neck cancer.
|Condition or disease||Intervention/treatment|
|Head and Neck Cancer||Genetic: microarray analysis Other: laboratory biomarker analysis|
- Identify gene expression profiles associated with survival by DNA microarray assay analysis using RNA from formalin-fixed paraffin-embedded tissue samples from patients with squamous cell carcinoma of the head and neck treated on clinical trial RTOG-9501.
OUTLINE: Formalin-fixed paraffin-embedded tissue samples are analyzed by DNA microarray analysis for gene expression profiling.
|Study Type :||Observational|
|Actual Enrollment :||29 participants|
|Official Title:||Survival Prediction in HNSCC Based on Gene Expression Profiles From FFPE Tissues|
|Study Start Date :||February 2005|
|Actual Primary Completion Date :||December 2007|
|Actual Study Completion Date :||December 2007|
Genetic: microarray analysis
- Identification of gene expression profiles used to predict survival as assessed by DNA microarray analysis [ Time Frame: at time of surgical resection ]
Biospecimen Retention: Samples With DNA
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00897052
|Principal Investigator:||Barbara Murphy, MD||Vanderbilt-Ingram Cancer Center|