Functional MRI Before and After Treatment for Depression
Recruitment status was Recruiting
The purpose of this study is to help us understand how depression changes brain activity and how this relates to mood, anxiety, and cognitive functions like memory. We also hope to develop a brain imaging test that will predict either before or within two weeks of starting a medicine whether the treatment will work.
|Study Design:||Allocation: Non-Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:||Functional MRI Before and After Treatment for Depression|
- Hamilton Depression Rating Scale [ Time Frame: end of 8 week period ] [ Designated as safety issue: Yes ]
- MADRS Rating Scale [ Time Frame: end of 8 week period ] [ Designated as safety issue: Yes ]
- Hamilton Anxiety Scale [ Time Frame: end of 8 week period ] [ Designated as safety issue: Yes ]
- Beck Depression Inventory (BDI) [ Time Frame: end of 8 week period ] [ Designated as safety issue: Yes ]
- Beck Anxiety Scale [ Time Frame: end of 8 week period ] [ Designated as safety issue: Yes ]
|Study Start Date:||February 2009|
|Estimated Study Completion Date:||February 2012|
|Estimated Primary Completion Date:||February 2012 (Final data collection date for primary outcome measure)|
Refer to Detailed Description Section for full description of intervention. Week 1 (baseline): Subject will complete several tests to assess the subject's memory and concentration. Following visit, they will begin treatment with the antidepressant citalopram.
Week 1 MRI: Subject will have their first MRI. Week 2 visit: Physician will meet with they to assess the subject's overall condition.
Week 2 MRI: Subject will have the subject's second MRI. Week 4 visit: The study physician will meet with the subject to assess their overall condition.
Week 6 (Telephone check-in): The study physician will check in with the subject by telephone to assess the subject's overall condition.
Week 8: (End-of-study visit) Subject will take repeated tests of memory and concentration. The study physician will also discuss recommendations for further treatment of the subject's depression.
Week 8 MRI: Around the time of the subject's week 8 visit they will have the subject's third and final MRI.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00896441
|Contact: Maureen H Chang, B.S.||(650) firstname.lastname@example.org|
|United States, California|
|Stanford University School of Medicine||Recruiting|
|Stanford, California, United States, 94305|
|Contact: Maureen H Chang, B.S. 650-725-4620 email@example.com|
|Contact: Jessica Hawkins, B.S. (650) 723-8323 firstname.lastname@example.org|
|Principal Investigator: Michael D Greicius|
|Sub-Investigator: Matthew White|
|Sub-Investigator: Charles DeBattista|
|Principal Investigator:||Michael D Greicius||Stanford University|