Critical Illness Neuromuscular Abnormalities in Neurocritical Care Patients
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The aim of this research is to investigate critical illness neuromuscular abnormalities in neurocritical care patients.
Condition or disease
Muscle WeaknessCritical Illness
Since 1984, the problem of critical illness neuromuscular abnormalities (CINMAs) has attracted considerable interest. According to these studies, CINMAs include the muscular weakness that accompanies critical illness resulting from polyneuropathy and/or myopathy and can be seen in 25-85% of cases of critically ill patients. Clinically, CINMAs present as symmetric flaccid tetraparesis and difficulty weaning off mechanical lung ventilation. However, these data are derived from treating non-specialized intensive care unit (ICU) patients. In this research, we wished to investigate CINMAs in neurocritical care patients. From day one of the patients' participation in the research and until a discharge from the ICU (or death), daily neurological surveys and weekly nerve conduction studies were performed. Based on the results of each nerve conduction study, an index of neuromuscular damage was noted to evaluate the severity of the CINMAs. Needle electromyography and muscle biopsy were not used
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Layout table for eligibility information
Ages Eligible for Study:
16 Years and older (Child, Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Patients from neurosurgical ICU in city clinical hospital
Age: 16 years and older
Acute primary cerebral pathology
Signs of systemic inflammatory response
Exclusion of the possibility of an initial pathology of the spinal cord, peripheral nervous system and muscles in past medical history
Brain stem or bilateral hemispheric lesions with tetraparesis at the onset of illness
Inability to perform high-grade nerve conduction studies