Psychosocial Adjustment of Adolescents With Spina Bifida (CHATS)
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Psychosocial Adjustment of Adolescents With Spina Bifida|
- Social functioning/peer relationships [ Time Frame: longitudinal during adolescent development ] [ Designated as safety issue: No ]
- Psychosocial adjustment [ Time Frame: longitudinal during adolescent development ] [ Designated as safety issue: No ]
|Study Start Date:||September 2005|
|Estimated Study Completion Date:||July 2019|
|Estimated Primary Completion Date:||July 2019 (Final data collection date for primary outcome measure)|
140 children with spina bifida (ages 8-15)
This study represents the critical next step in our developmentally-oriented program of research on the psychosocial adjustment of adolescents with spina bifida. Previously, we conducted a 10-year longitudinal study of family relationships and adjustment in such children and found that early family relationship variables were highly salient in the prediction of subsequent trajectories of adjustment. Moreover, adolescents with spina bifida were found to exhibit psychosocial adjustment difficulties, including significant social problems (i.e., social immaturity and passivity, less social contact with friends). This prior study was a between-groups investigation where children with spina bifida were compared with able-bodied comparison children and was the first of its kind to include an assessment of observed family interaction in children with spina bifida.
To understand better the underlying mechanisms that account for these significant psychosocial difficulties, funding is sought for a new within-group longitudinal study of children with spina bifida as they traverse the early adolescent stage of development. Unlike our previous study, this investigation will include a thorough assessment of children's peer relationships and neuropsychological factors as potential predictors of variability in psychosocial adjustment outcomes. The proposed study will be the first to collect observed peer interaction data (target child with close friend) in adolescents with spina bifida. Moreover, we will examine the degree to which neuropsychological limitations experienced by children with spina bifida may contribute to their social difficulties.
Thus, a developmentally-oriented bio-neuropsychosocial model of psychological adjustment will be evaluated in young adolescents with spina bifida (see Figure 1). Extensive multi-source and multi-method data will be collected across several predictor variable domains: (1) biological (i.e., severity of disability, current and past health status, pubertal development), (2) neuropsychological (i.e., executive functions and attention, language pragmatics and inference making skills, emotion recognition), and (3) social (i.e., observed and perceived social behaviors with peers and family). A multidimensional perspective on adolescent adjustment will also be adopted insofar as the following constructs will be assessed: internalizing symptoms (e.g., depression), externalizing symptoms (e.g., aggression), social adjustment, quality of life and functional status, school performance, autonomy development, and medical adherence (see Figure 1).
Participants will include a sample of 140 children and young adolescents with spina bifida (with meningomyelocele [MM] and shunted hydrocephalus; 10-13 years old at Time 1 and 12-15 years old at Time 2), along with their parents and a close friend. Spanish-speaking Hispanic/Latino families will also be recruited (given the high relative prevalence of spina bifida in this population), constituting approximately 20% of the sample. Teacher- and health professional-reported data and medical chart information will also be collected. Questionnaire, interview, neuropsychological testing, and observational methods will be employed during two home visits at Time 1 and two home visits at Time 2. Videotapes of family and peer interactions will be coded by trained graduate and undergraduate students.
In addition to testing the utility of the bio-neuropsychosocial model, several mediational and moderational models will also be tested (see Figures 2 and 3) within the context of the more general model in Figure 1. Such models will facilitate identification of underlying mechanisms for associations between variables (i.e., mediational models) and will attempt to isolate variables within one domain that compensate for deficits in another domain (i.e., moderational models). Findings of this study will provide information on the differential relevance of family relationships, peer relationships, neuropsychological factors, and biological factors for adjustment in adolescents with spina bifida. Moreover, the results will have implications for prevention and intervention efforts with families who have offspring with disabling birth defects (Dryfoos, 1990).
Please refer to this study by its ClinicalTrials.gov identifier: NCT00891891
|United States, Illinois|
|Loyola University Chicago|
|Chicago, Illinois, United States, 60626|
|Principal Investigator:||Grayson N Holmbeck, PhD||Loyola University Chicago|