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Predictors of Neuro-cognitive Decline and Survival in HIV-infected Subjects

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00864292
Recruitment Status : Completed
First Posted : March 18, 2009
Last Update Posted : May 3, 2011
Thai Red Cross AIDS Research Centre
Information provided by:
South East Asia Research Collaboration with Hawaii

Brief Summary:

Patients will be followed every 6 months for a total of 5 visits (Month 0, 6, 12, 18 and 24). The first visit is the screening and entry visit which can occur at any time after the subject finishes SEARCH 001 study but preferably it should occur approximately 6 months after SEARCH 001 study completion.

At each visit, patients will undergo the following

  1. Assessment of function including activity of daily living questionnaire
  2. History of medical illnesses, medication history
  3. Neurological examination: All patients will have a neurological evaluation and neuropsychological evaluation to characterize neurocognitive and neurological status. (It is possible that patients within the non-dementia group will meet criteria for dementia after close testing is completed).
  4. Neuropsychological assessment:
  5. Thai Depression Inventory.
  6. HIV viral load and storage of blood for proviral DNA level

Final outcome assessment based on all available data. If possible, it is intended that these diagnoses will be determined through monthly VTC conference calls with UH investigators. This consensus conference will include the Thai investigators, the UH neurologist, the UH neuropsychologist and the UH principal investigators.

Condition or disease
AIDS Dementia

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Study Type : Observational
Actual Enrollment : 60 participants
Observational Model: Case-Control
Time Perspective: Prospective
Study Start Date : August 2007
Actual Primary Completion Date : April 2011
Actual Study Completion Date : April 2011

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Dementia HIV/AIDS

HIV-infected, no dementia
Patients with HIV-infection but no dementia
HIV-infected, dementia
Patients with HIV-infection and dementia

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
primary care clinic

Inclusion Criteria:

  • All patients who have completed the SEARCH 001 study are eligible to enroll in this SEARCH 001.1 study provided that they understand and voluntarily sign the informed consent form.

Exclusion Criteria:

  • None

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00864292

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South East Asia Research Collaboration with Hawaii
Bangkok, Thailand, 10330
Sponsors and Collaborators
South East Asia Research Collaboration with Hawaii
Thai Red Cross AIDS Research Centre
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Principal Investigator: Jintanat Ananworanich, PhD South East Asia Research Collaboration with Hawaii
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Responsible Party: Victor Valcour, John A. Burns School of Medicine, Honolulu, Hawaii Identifier: NCT00864292    
Other Study ID Numbers: SEARCH 001.1
First Posted: March 18, 2009    Key Record Dates
Last Update Posted: May 3, 2011
Last Verified: March 2009
Additional relevant MeSH terms:
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Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Neurocognitive Disorders
Mental Disorders