Postprandial Endothelial Dysfunction After a High-Fat Meal in HIV-infected Men (PERTH)
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ClinicalTrials.gov Identifier: NCT00846599 |
Recruitment Status
:
Completed
First Posted
: February 18, 2009
Last Update Posted
: October 12, 2017
|
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Condition or disease | Intervention/treatment |
---|---|
HIV Infection Cardiovascular Risk HIV Infections | Other: Omega-3 study meal Other: Saturated fat study meal |
Study Type : | Observational |
Estimated Enrollment : | 50 participants |
Observational Model: | Case-Control |
Time Perspective: | Cross-Sectional |
Official Title: | Postprandial Endothelial Dysfunction After a High-Fat Meal in HIV-infected Men |
Study Start Date : | January 2008 |
Actual Primary Completion Date : | January 2010 |
Actual Study Completion Date : | January 2010 |

Group/Cohort | Intervention/treatment |
---|---|
1
High omega-3
|
Other: Omega-3 study meal
Participant will eat a study meal high in omega-3 fatty acids.
|
2
High saturated fat
|
Other: Saturated fat study meal
Participant will eat a study meal high in saturated fat.
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- To measure flow-mediated dilation before and after eating the two study meals. [ Time Frame: Study visit 1 and 2 ]
- To compare the effect of different dietary fats on endothelial function. [ Time Frame: Study visit 1 and 2 ]

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Ages Eligible for Study: | 18 Years and older (Adult, Senior) |
Sexes Eligible for Study: | Male |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Probability Sample |
Inclusion Criteria:
- HIV-positive white male aged >18 years
-
Under one of the following treatment categories:
- Treatment naive or have never taken any HIV medications
- Taking Kaletra
- Taking Sustiva
- Taking Atripla
Exclusion Criteria:
- Smoker
-
Pre-existing diagnosis or treatment for the following:
- Lipid disorder
- Cardiovascular disease
- High blood pressure
- Diabetes
- Acute opportunistic infection or malignancy within last 3 months or current therapy for either
- Active IV drug use

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00846599
United States, Massachusetts | |
Tufts University | |
Boston, Massachusetts, United States, 02111 |
Principal Investigator: | Alexandra Mangili, MD, MPH | Tufts University School of Medicine |
Additional Information:
Responsible Party: | Alexandra Mangili, MD, MPH, Tufts University School of Medicine |
ClinicalTrials.gov Identifier: | NCT00846599 History of Changes |
Other Study ID Numbers: |
SUB730 |
First Posted: | February 18, 2009 Key Record Dates |
Last Update Posted: | October 12, 2017 |
Last Verified: | October 2017 |
Keywords provided by Tufts University:
brachial artery ultrasound brachial artery reactivity HIV human immunodeficiency virus cardiovascular risk omega three |
saturated fat sustiva atripla kaletra treatment naive |
Additional relevant MeSH terms:
Infection Communicable Diseases HIV Infections Acquired Immunodeficiency Syndrome Lentivirus Infections Retroviridae Infections RNA Virus Infections |
Virus Diseases Sexually Transmitted Diseases, Viral Sexually Transmitted Diseases Immunologic Deficiency Syndromes Immune System Diseases Slow Virus Diseases |