Epidemiology and Pathogenesis of HIV-Associated Pulmonary Hypertension
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ClinicalTrials.gov Identifier: NCT00845013 |
Recruitment Status
:
Active, not recruiting
First Posted
: February 16, 2009
Last Update Posted
: June 2, 2015
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Condition or disease |
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HIV Infection Pulmonary Hypertension Endothelial Function HIV Infections |
Study Type : | Observational |
Estimated Enrollment : | 125 participants |
Observational Model: | Cohort |
Time Perspective: | Prospective |
Official Title: | Epidemiology and Pathogenesis of HIV-Associated Pulmonary Hypertension |
Study Start Date : | November 2007 |
Estimated Primary Completion Date : | June 2019 |
Estimated Study Completion Date : | June 2019 |
Group/Cohort |
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HIV Infection
HIV-infected individuals with the clinical diagnosis of pulmonary hypertension or HIV-infected individuals who have mildly elevated pulmonary arterial pressures
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- pulmonary artery pressure [ Time Frame: 3 years ]
Biospecimen Retention: Samples With DNA

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Ages Eligible for Study: | 18 Years and older (Adult, Senior) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
Inclusion Criteria:
- Infection with HIV greater than 6 months in duration
- Right heart catheterization showing PASP > 30mm Hg
- Ability to provide reliable history of HIV medications or has received the majority of medical care from San Francisco General Hospital with available records of medical treatment.
- Ability to participate in follow-up for the duration of the study.
Exclusion Criteria:
- Known significant cardiovascular disease, including clinically significant valvular heart disease, congenital heart disease, current or prior symptomatic coronary disease, or known cardiomyopathy.
- Any known pulmonary disease that could potentially cause pulmonary hypertension.
- A pO2 by pulse oximetry below 90% on room air.
- Obstructive sleep apnea.
- Known collagen vascular disease.
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History of anorexigen use
- 7. Age less than 18 years old.
- 8. Other co-morbidities for which the investigators, in conjunction with the primary care provider, believe render the participant with an expected survival of 6 months or less.

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00845013
United States, California | |
University of California, San Francisco | |
San Francisco, California, United States, 94110 |
Responsible Party: | University of California, San Francisco |
ClinicalTrials.gov Identifier: | NCT00845013 History of Changes |
Other Study ID Numbers: |
HIVPAP |
First Posted: | February 16, 2009 Key Record Dates |
Last Update Posted: | June 2, 2015 |
Last Verified: | May 2015 |
Keywords provided by University of California, San Francisco:
HIV infection pulmonary hypertension endothelial function antiretroviral medication Treatment Experienced |
Additional relevant MeSH terms:
Infection Communicable Diseases Hypertension HIV Infections Acquired Immunodeficiency Syndrome Hypertension, Pulmonary Vascular Diseases Cardiovascular Diseases Lentivirus Infections Retroviridae Infections |
RNA Virus Infections Virus Diseases Sexually Transmitted Diseases, Viral Sexually Transmitted Diseases Immunologic Deficiency Syndromes Immune System Diseases Slow Virus Diseases Lung Diseases Respiratory Tract Diseases |