Influence of Non-steroidal Anti-inflammatory Drugs (NSAID) on Muscle Regeneration
The purpose of this study is to determine the influence of non-steroidal anti-inflammatory drugs (NSAIDs) on muscle regeneration.
The investigators' hypothesis is that ingestion of NSAID will delay or impair muscle regeneration.
|Study Design:||Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Investigator, Outcomes Assessor)
Primary Purpose: Basic Science
|Official Title:||The Influence of Blocking Inflammatory Activity in Vivo on Skeletal Muscle Regeneration in Humans|
- Muscle regeneration [ Time Frame: 1 month ] [ Designated as safety issue: No ]
- Muscle strength [ Time Frame: 1 month ] [ Designated as safety issue: No ]
|Study Start Date:||April 2009|
|Study Completion Date:||December 2009|
|Primary Completion Date:||December 2009 (Final data collection date for primary outcome measure)|
Effect of NSAID ingestion on muscle regeneration
Placebo Comparator: Placebo
The model employed to induce muscle damage is electrical stimulation. Muscle biopsies will be examined to follow the response of satellite cells and muscle regeneration. Study participants will be randomly assigned to a placebo or NSAID group in a double-blinded manner.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00832663
|Copenhagen, NV, Denmark, 2400|
|Principal Investigator:||Abigail L Mackey, PhD||Institute of Sports Medicine Copenhagen, Bispebjerg Hospital|