ClinicalTrials.gov
ClinicalTrials.gov Menu

Improving Human Ovarian Transplantation

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT00827476
Recruitment Status : Unknown
Verified January 2009 by Hadassah Medical Organization.
Recruitment status was:  Active, not recruiting
First Posted : January 22, 2009
Last Update Posted : January 22, 2009
Sponsor:
Collaborator:
Israel Science Foundation
Information provided by:
Hadassah Medical Organization

Brief Summary:
we will perform xenotransplantation and in vitro culture of ovarian tissue from patients undergoing ovarian cortex cryopreservation.

Condition or disease Intervention/treatment Phase
Fertility Preservation Procedure: ovarian transplantation Early Phase 1

Detailed Description:
Ovarian tissue is removed by laparoscopy and only in patients facing premature ovarian failure due to chemotherapy.Tissue for research will consist either of a small portion (<10%) of the cortex for preservation for young women. another source of ovarian tissue for research will be obtained following consent from family of patients who have died of the disease and have previously frozen ovarian tissue.

Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 100 participants
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Phase 1 Study to Improve Results of Human Ovarian Transplantation
Study Start Date : January 2009
Estimated Primary Completion Date : January 2012
Estimated Study Completion Date : January 2015

Arm Intervention/treatment
Experimental: ovarian transplantation
tissue will be used for xenotransplantation or in vitro culture
Procedure: ovarian transplantation
ovarian xenotransplantation or in vitro culture




Primary Outcome Measures :
  1. improving folliculogenesis and oocuyte maturation after ovarian transplantation [ Time Frame: 2 years ]


Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   5 Years to 40 Years   (Child, Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • tissue previously obtained

Exclusion Criteria:

  • no tissue available or no consent

Responsible Party: Ariel Revel, Hadassah Medical Organization
ClinicalTrials.gov Identifier: NCT00827476     History of Changes
Other Study ID Numbers: 0530-08-HMO- CTIL
First Posted: January 22, 2009    Key Record Dates
Last Update Posted: January 22, 2009
Last Verified: January 2009

Keywords provided by Hadassah Medical Organization:
ovary
human
transplantaion
ovarian failure