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Improving Human Ovarian Transplantation

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified January 2009 by Hadassah Medical Organization.
Recruitment status was:  Active, not recruiting
Israel Science Foundation
Information provided by:
Hadassah Medical Organization Identifier:
First received: January 21, 2009
Last updated: NA
Last verified: January 2009
History: No changes posted
we will perform xenotransplantation and in vitro culture of ovarian tissue from patients undergoing ovarian cortex cryopreservation.

Condition Intervention Phase
Fertility Preservation Procedure: ovarian transplantation Early Phase 1

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Phase 1 Study to Improve Results of Human Ovarian Transplantation

Further study details as provided by Hadassah Medical Organization:

Primary Outcome Measures:
  • improving folliculogenesis and oocuyte maturation after ovarian transplantation [ Time Frame: 2 years ]

Estimated Enrollment: 100
Study Start Date: January 2009
Estimated Study Completion Date: January 2015
Estimated Primary Completion Date: January 2012 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: ovarian transplantation
tissue will be used for xenotransplantation or in vitro culture
Procedure: ovarian transplantation
ovarian xenotransplantation or in vitro culture

Detailed Description:
Ovarian tissue is removed by laparoscopy and only in patients facing premature ovarian failure due to chemotherapy.Tissue for research will consist either of a small portion (<10%) of the cortex for preservation for young women. another source of ovarian tissue for research will be obtained following consent from family of patients who have died of the disease and have previously frozen ovarian tissue.

Ages Eligible for Study:   5 Years to 40 Years   (Child, Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • tissue previously obtained

Exclusion Criteria:

  • no tissue available or no consent
  Contacts and Locations
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No Contacts or Locations Provided
  More Information

Responsible Party: Ariel Revel, Hadassah Medical Organization Identifier: NCT00827476     History of Changes
Other Study ID Numbers: 0530-08-HMO- CTIL
Study First Received: January 21, 2009
Last Updated: January 21, 2009

Keywords provided by Hadassah Medical Organization:
ovarian failure processed this record on September 21, 2017