Improvement of Language Disturbances After Stroke by Intensive Training and Electrical Brain Stimulation

The recruitment status of this study is unknown because the information has not been verified recently.
Verified January 2009 by University Hospital Muenster.
Recruitment status was  Recruiting
Information provided by:
University Hospital Muenster Identifier:
First received: January 13, 2009
Last updated: NA
Last verified: January 2009
History: No changes posted
The study aims to identify if intensive language training, consisting mainly of computer-based object naming, together with electrical brain stimulation, will lead to an improvement of language functions in patients that suffer from language disturbances after a stroke.

Condition Intervention Phase
Device: anodal tDCS
Device: cathodal tDCS
Device: sham stimulation
Phase 2
Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Crossover Assignment
Masking: Double Blind (Subject, Outcomes Assessor)
Primary Purpose: Treatment
Official Title: Improvement of Aphasia After Stroke by Intensive Training and Transcranial Direct Current Stimulation

Resource links provided by NLM:

Further study details as provided by University Hospital Muenster:

Primary Outcome Measures:
  • Number of words correctly named after training plus tDCS [ Time Frame: 1 year ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Communicative-Activity-Log & Stroke-and-Aphasia-Quality-of-Life-Scale [ Time Frame: 1 year ] [ Designated as safety issue: Yes ]

Estimated Enrollment: 20
Study Start Date: January 2009
Estimated Study Completion Date: December 2009
Estimated Primary Completion Date: December 2009 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: anodal tDCS Device: anodal tDCS
anodal transcranial direct current stimulation
Active Comparator: 2
cathodal tDCS
Device: cathodal tDCS
cathodal transcranial direct current stimulation
Placebo Comparator: 3
sham stimulation
Device: sham stimulation
sham stimulation


Ages Eligible for Study:   18 Years to 80 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • chronic stroke (> 1 year after event)
  • aphasia due to stroke with naming impairment
  • German as first language
  • first-ever stroke

Exclusion Criteria:

  • more than 1 stroke
  • progressive stroke
  • history of severe alcohol or drug abuse, psychiatric illnessess like severe depression, poor motivational capacity
  • dementia
  • contraindications for Magnetic Resonance Imaging
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00822068

Contact: Agnes Floel, MD 0049 251 83 ext 45699
Contact: Caterina Breitenstein, PhD 0049 251 83 ext 49969

Department of Neurology, University of Muenster; Department of Neurology, University of Berlin Recruiting
Muenster / Berlin, NRW/Berlin-Brandenburg, Germany, 48129/10098
Contact: Agnes Floel, MD    +49 251 83 ext 45699   
Contact: Caterina Breiteinstein, PhD   
Principal Investigator: Agnes Floel, MD         
Sponsors and Collaborators
University Hospital Muenster
Principal Investigator: Agnes Floel, MD Department of Neurology, University of Muenster; Department of Neurology, University of Berlin, Germany
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Department of Neurology, University of Muenster Identifier: NCT00822068     History of Changes
Other Study ID Numbers: Aphasia_tDCS 
Study First Received: January 13, 2009
Last Updated: January 13, 2009
Health Authority: Germany: German Board of Psychology

Keywords provided by University Hospital Muenster:
transcranial direct current stimulation
intensive training
chronic aphasia after stroke

Additional relevant MeSH terms:
Brain Diseases
Cardiovascular Diseases
Central Nervous System Diseases
Cerebrovascular Disorders
Communication Disorders
Language Disorders
Nervous System Diseases
Neurobehavioral Manifestations
Neurologic Manifestations
Signs and Symptoms
Speech Disorders
Vascular Diseases processed this record on May 26, 2016