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Long-Standing Persistant Atrial Fibrillation-Pulmonary Vein Isolation With or Without Ablation (Alster-Lost)

This study has been completed.
Information provided by (Responsible Party):
Asklepios proresearch Identifier:
First received: January 9, 2009
Last updated: February 6, 2017
Last verified: February 2017
The chronic success rate, defined as freedom from any atrial tachyarrhythmias will increase from 35% to 60% by ablation of complex fragmented atrial electrograms potentials in addition to pulmonary vein isolation (PVI) as compared to PVI alone in patients with long-standing persistent AF.

Condition Intervention
Atrial Fibrillation
Procedure: pulmonary vein isolation
Procedure: pulmonary vein isolation with additional ablation of fragmented potentials

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Participant
Primary Purpose: Treatment
Official Title: Ablation at St. Georg Hospital for Long-Standing Persistent Atrial Fibrillation - Pulmonary Vein Isolation With or Without Ablation of Complex Fragmented Atrial Potentials

Resource links provided by NLM:

Further study details as provided by Asklepios proresearch:

Primary Outcome Measures:
  • data collection in view of acute and chronic success rate [ Time Frame: 12 months ]

Secondary Outcome Measures:
  • data collection of complications in both groups and also procedure parameters [ Time Frame: 12 months ]

Enrollment: 124
Study Start Date: May 2008
Study Completion Date: February 2017
Primary Completion Date: February 2017 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: 1
ablation: pulmonary vein isolation
Procedure: pulmonary vein isolation
common pulmonary vein isolation procedure
Active Comparator: 2
ablation: pulmonary vein isolation with additional ablation of fragmented potentials
Procedure: pulmonary vein isolation with additional ablation of fragmented potentials
common pulmonary vein isolation with additional but also common ablation of fragmented potentials


Ages Eligible for Study:   18 Years to 75 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • long standing persistent atrial fibrillation > 6 months and < 5 years

Exclusion Criteria:

  • renal failure
  • left atrial size >55 mm
  Contacts and Locations
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Please refer to this study by its identifier: NCT00820625

Asklepios Klinik St. Georg
Hamburg, Germany
Sponsors and Collaborators
Asklepios proresearch
Principal Investigator: Karl-Heinz Kuck, PhD, MD Asklepios Klinik St. Georg, Department of Cardiology
  More Information

Responsible Party: Asklepios proresearch Identifier: NCT00820625     History of Changes
Other Study ID Numbers: 1787
PV 2961 ( Other Identifier: Ethical Board Hamburg )
Study First Received: January 9, 2009
Last Updated: February 6, 2017
Individual Participant Data  
Plan to Share IPD: Undecided

Additional relevant MeSH terms:
Atrial Fibrillation
Arrhythmias, Cardiac
Heart Diseases
Cardiovascular Diseases
Pathologic Processes processed this record on April 26, 2017