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Examination of B Cell Responses in Human Blood

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ClinicalTrials.gov Identifier: NCT00806845
Recruitment Status : Completed
First Posted : December 11, 2008
Last Update Posted : May 13, 2015
Sponsor:
Collaborator:
Information provided by (Responsible Party):

Study Description
Brief Summary:
The aim of this study is the assessment B-cell immune responses in HIV-infected individuals.

Condition or disease
HIV Infections

Detailed Description:
Groups of patients with different immune competencies will be examined. The impact of HIV infection on immune response will be assessed.

Study Design

Study Type : Observational
Actual Enrollment : 50 participants
Observational Model: Cohort
Time Perspective: Cross-Sectional
Official Title: Gewinnung Humaner antikörperproduzierender Zellen Aus Dem Blut
Study Start Date : July 2008
Primary Completion Date : December 2009
Study Completion Date : February 2010

Resource links provided by the National Library of Medicine

MedlinePlus related topics: HIV/AIDS
U.S. FDA Resources

Groups and Cohorts

Group/Cohort
HIV infected individuals, HIV controllers
CD4+ T cell count > 350/µl, HIV load < 1000 copies/ml
HIV infected individuals, early progressors
CD4+ T cell count > 350/µl, HIV load > 1000 copies/ml
HIV infected individuals, late progressors
CD4+ T cell count < 200/µl
HIV infected individuals, late progressors with therapy
CD4+ T cell count < 200/µl, under ART
Healthy individuals
Uninfected


Outcome Measures

Primary Outcome Measures :
  1. Antigen specific B-cell responses [ Time Frame: 18 months ]

Biospecimen Retention:   Samples Without DNA
peripheral blood

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 65 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
HIV patients and controls attending specialised clinics, Germany
Criteria

Inclusion Criteria:

  • HIV-infected individuals
  • controls

Exclusion Criteria:

- none

Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00806845


Locations
Germany
Universität Leipzig
Leipzig, Sachsen, Germany, 04103
Sponsors and Collaborators
Regenerative Medicine Network
University of Leipzig
Investigators
Study Director: Christian Jassoy, MD Universität Leipzig
More Information

Publications:
Responsible Party: Christian Jassoy, Professor of Virology, Regenerative Medicine Network
ClinicalTrials.gov Identifier: NCT00806845     History of Changes
Other Study ID Numbers: RegMedNet-001
First Posted: December 11, 2008    Key Record Dates
Last Update Posted: May 13, 2015
Last Verified: May 2015

Keywords provided by Christian Jassoy, Regenerative Medicine Network:
HIV
B-lymphocyte

Additional relevant MeSH terms:
HIV Infections
Lentivirus Infections
Retroviridae Infections
RNA Virus Infections
Virus Diseases
Sexually Transmitted Diseases, Viral
Sexually Transmitted Diseases
Immunologic Deficiency Syndromes
Immune System Diseases