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Prospective Evaluation of the Preoperative Lymph Node Staging in Patients With Cancer of the Esophagogastric Junction and Stomach

This study has been withdrawn prior to enrollment.
Information provided by (Responsible Party):
University of Zurich Identifier:
First received: November 28, 2008
Last updated: June 22, 2016
Last verified: June 2016

This prospective study includes patients with histologically proven cancer of the esophagogastric junction (Siewert Type II and III) and the stomach. Aim of the study is to evaluate the accuracy of PET-CT for the preoperative assessment of lymph node metastasis. The evaluation includes a combination with standard diagnostic tools (endoluminal ultrasound, CT and diagnostic laparoscopy prior to neoadjuvant therapy). Standardized D2-lymphadenectomy is performed and individual lymph node stations (Nr 1-12 according to the Japanese classification) are histopathologically examined. Furthermore we evaluate the role of the PET-CT for early metabolic response evaluation in patients receiving neoadjuvant chemotherapy.

  • Trial with surgical intervention

Condition Intervention Phase
Stomach Cancer
Cancer of Esophagogastric Junction
Procedure: FDG-PET-CT
Phase 2

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Single Group Assignment
Masking: Single Blind (Investigator)
Primary Purpose: Diagnostic

Resource links provided by NLM:

Further study details as provided by University of Zurich:

Primary Outcome Measures:
  • Diagnostic Accuracy of PET-CT [ Time Frame: preoperative ] [ Designated as safety issue: No ]

Enrollment: 0
Study Start Date: October 2008
Estimated Primary Completion Date: January 2015 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
all patients
all patients with Adenocarcinoma
Procedure: FDG-PET-CT
Radiologic standard procedure


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Inclusion criteria:

  • Histological prove of adenocarcinoma of the stomach.

Exclusion criteria:

  • Recurrent gastric carcinoma
  • No informed consent
  • Previous malignancy (exception: thyroid, bladder in situ, Cervix in situ)
  Contacts and Locations
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Please refer to this study by its identifier: NCT00800969

Zurich, Switzerland
Sponsors and Collaborators
University of Zurich
Principal Investigator: Kuno Lehmann, MD University Hospital Zurich, Visceral surgery
  More Information

Responsible Party: University of Zurich Identifier: NCT00800969     History of Changes
Other Study ID Numbers: VIS-UGI-1 
Study First Received: November 28, 2008
Last Updated: June 22, 2016
Health Authority: Switzerland: Ethikkommission

Keywords provided by University of Zurich:
Adenocarcinoma of the stomach and esophagogastric junction

Additional relevant MeSH terms:
Stomach Neoplasms
Neoplasms, Glandular and Epithelial
Neoplasms by Histologic Type
Gastrointestinal Neoplasms
Digestive System Neoplasms
Neoplasms by Site
Digestive System Diseases
Gastrointestinal Diseases
Stomach Diseases processed this record on October 27, 2016