Increased Expression of Adiponectin Receptor 2 in the Mononuclear Cells in Children With Prader-Willi Syndrome

This study has been completed.
Information provided by:
Samsung Medical Center Identifier:
First received: November 30, 2008
Last updated: December 1, 2008
Last verified: November 2008

The inflammatory process is involved in the pathogenesis of obesity. Prader-Willi syndrome (PWS) is a genetic model of syndromic obesity. Adiponectin is an adipokine with potent anti-inflammatory properties, and its effect is mediated through adiponectin receptors 1 (adipoR1) and 2 (adipoR2).

Objective of this study is to compare the expression of adipoR1, adipoR2, and adiponectin in peripheral blood mononuclear cells (PBMCs) in PWS children and obese control and to correlate receptor expression with insulin sensitivity and obesity-related parameters.

Prader-Willi Syndrome

Study Type: Observational
Official Title: Increased Expression of Adiponectin Receptor 2 in the Mononuclear Cells in Children With Prader-Willi Syndrome

Resource links provided by NLM:

Further study details as provided by Samsung Medical Center:


Ages Eligible for Study:   up to 18 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
Fourteen children with PWS and control subjects

Inclusion Criteria:

  • children with Prader-willi syndrome
  • children with simple obesity

Exclusion Criteria:

  • subjects with diabetes mellitus (fasting plasma glucose > 126 mg/dL with a 2-h oral glucose tolerance test value of >200 mg/dl)
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Please refer to this study by its identifier: NCT00800852

Sponsors and Collaborators
Samsung Medical Center
Principal Investigator: Don-Kyu Jin, M.D. Samsung Medical Center, Sungkyunkwan Uiversity School of Medicine
  More Information

Responsible Party: Dong-Kyu Jin, Samsung Medical Center Identifier: NCT00800852     History of Changes
Other Study ID Numbers: 2008-10-040 
Study First Received: November 30, 2008
Last Updated: December 1, 2008
Health Authority: Korea: Food and Drug Administration

Keywords provided by Samsung Medical Center:
adiponectin receptor
Prader-Willi syndrome

Additional relevant MeSH terms:
Prader-Willi Syndrome
Abnormalities, Multiple
Chromosome Disorders
Congenital Abnormalities
Genetic Diseases, Inborn
Intellectual Disability
Nervous System Diseases
Neurobehavioral Manifestations
Neurologic Manifestations
Nutrition Disorders
Pathologic Processes processed this record on May 26, 2016