Prenatal Corticosteroids and Antioxidants in Preterm Infants (RESOX)
|Study Design:||Observational Model: Case Control
Time Perspective: Prospective
|Official Title:||Prenatal Corticosteroids Enhance the Antioxidant Defense System in Extremely Low Gestational Age Neonates|
- Evaluation of glutathione redox status in cord blood. [ Time Frame: at birth ] [ Designated as safety issue: No ]
- Evaluation of antioxidant activity. [ Time Frame: at birth ] [ Designated as safety issue: No ]
|Study Start Date:||January 2003|
|Study Completion Date:||January 2005|
|Primary Completion Date:||January 2005 (Final data collection date for primary outcome measure)|
Extremely low gestational age neonates (<28 weeks gestation) whose mothers received full course of betamethasone before delivery.
NON PRENATAL CORTICOSTEROIDS
Extremely low gestational age neonates (<28 weeks gestation) whose mothers did not receive full course of betamethasone before delivery.
This is an observational study recruiting extremely low gestational age neonates (<28 weeks gestation) whose mothers received or not full scheduled prenatal glucocorticosteroids. Healthy term newly born infants acted as controls.
At birth cord blood were drawn for the following analytical determinations: reduced and oxidized glutathione; malondialdehyde; superoxide dismutase; catalase; glutathione peroxidase; glutathione reductase; glutathione s-transferase. In addition, first urine voided was collected for ortho-tyrosine/phenylalanine and 8-hydroxy-2-oxo-deoxyguanosine/2-deoxyguanosine determination. Analytical data and clinical outcomes are compared.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00791687
|Division of Neonatology; University Hospital La Fe|
|Valencia, Spain, 46009|
|Principal Investigator:||MAXIMO VENTO, PHD, MD||Valencian Agency of Health|