Prenatal Corticosteroids and Antioxidants in Preterm Infants (RESOX)
|ClinicalTrials.gov Identifier: NCT00791687|
Recruitment Status : Completed
First Posted : November 14, 2008
Last Update Posted : November 14, 2008
|Condition or disease|
This is an observational study recruiting extremely low gestational age neonates (<28 weeks gestation) whose mothers received or not full scheduled prenatal glucocorticosteroids. Healthy term newly born infants acted as controls.
At birth cord blood were drawn for the following analytical determinations: reduced and oxidized glutathione; malondialdehyde; superoxide dismutase; catalase; glutathione peroxidase; glutathione reductase; glutathione s-transferase. In addition, first urine voided was collected for ortho-tyrosine/phenylalanine and 8-hydroxy-2-oxo-deoxyguanosine/2-deoxyguanosine determination. Analytical data and clinical outcomes are compared.
|Study Type :||Observational|
|Actual Enrollment :||57 participants|
|Observational Model:||Case Control|
|Official Title:||Prenatal Corticosteroids Enhance the Antioxidant Defense System in Extremely Low Gestational Age Neonates|
|Study Start Date :||January 2003|
|Actual Primary Completion Date :||January 2005|
|Actual Study Completion Date :||January 2005|
Extremely low gestational age neonates (<28 weeks gestation) whose mothers received full course of betamethasone before delivery.
NON PRENATAL CORTICOSTEROIDS
Extremely low gestational age neonates (<28 weeks gestation) whose mothers did not receive full course of betamethasone before delivery.
- Evaluation of glutathione redox status in cord blood. [ Time Frame: at birth ]
- Evaluation of antioxidant activity. [ Time Frame: at birth ]
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00791687
|Division of Neonatology; University Hospital La Fe|
|Valencia, Spain, 46009|
|Principal Investigator:||MAXIMO VENTO, PHD, MD||Valencian Agency of Health|