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Middle and Inner Ear Malformation in Children With Velocardiofacial Syndrome

This study has been completed.
Information provided by:
Pontificia Universidade Catolica de Sao Paulo Identifier:
First received: October 31, 2008
Last updated: NA
Last verified: October 2008
History: No changes posted
Middle and inner ear malformations on two boys with velocardiofacial syndrome are discussed.Special attention should be given to the presence of hearing loss due to middle and inner ear malformations, in addition to frequent conductive hearing loss regarding mastoid and middle ear inflammatory processes.

Ear Malformations in the Velocardiofacial Syndrome

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Middle and Inner Ear Malformation in Children With Velocardiofacial Syndrome

Resource links provided by NLM:

Further study details as provided by Pontificia Universidade Catolica de Sao Paulo:

Enrollment: 2
Study Start Date: January 2007
Study Completion Date: June 2007
Primary Completion Date: March 2007 (Final data collection date for primary outcome measure)
Detailed Description:
Two boys with clinical signs of velocardiofacial syndrome, at ages of 4.7 and 6,7 years old are the subjects of this study.Audiological evaluation, including pure tone audiometry, tympanometry, acoustical reflex, and Computerized Tomography of temporal bones, and analyses of DNA sample with markers of 22q11 region were performed.

Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Children with velocardiofacial syndrome

Inclusion Criteria:

  • Subjects with velocardiofacial syndrome
  Contacts and Locations
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Please refer to this study by its identifier: NCT00784173

Sponsors and Collaborators
Pontificia Universidade Catolica de Sao Paulo
Principal Investigator: Alfredo Tabith-Junior, MD Pontificia Universidade Católica de São Paulo
  More Information

Responsible Party: Alfredo Tabith Junior, Pontificia Universidade Catolica de São Paulo Identifier: NCT00784173     History of Changes
Other Study ID Numbers: Unique protocol
Study First Received: October 31, 2008
Last Updated: October 31, 2008

Keywords provided by Pontificia Universidade Catolica de Sao Paulo:
Middle ear
Inner ear

Additional relevant MeSH terms:
Congenital Abnormalities
DiGeorge Syndrome
Pathologic Processes
22q11 Deletion Syndrome
Craniofacial Abnormalities
Musculoskeletal Abnormalities
Musculoskeletal Diseases
Heart Defects, Congenital
Cardiovascular Abnormalities
Cardiovascular Diseases
Heart Diseases
Lymphatic Abnormalities
Lymphatic Diseases
Abnormalities, Multiple
Chromosome Disorders
Genetic Diseases, Inborn
Parathyroid Diseases
Endocrine System Diseases processed this record on May 25, 2017