Try our beta test site
IMPORTANT: Listing of a study on this site does not reflect endorsement by the National Institutes of Health. Talk with a trusted healthcare professional before volunteering for a study. Read more...

Interest of the Induction With Target-controlled Inhalation of Sevoflurane on Spikes Wave Occurrence (SIZE)

This study has been completed.
Information provided by (Responsible Party):
University Hospital, Bordeaux Identifier:
First received: October 17, 2008
Last updated: May 17, 2013
Last verified: May 2013
Sevoflurane is widely used for induction of anaesthesia. Several studies showed EEG abnormalities during mask induction with sevoflurane. The aim of our study was to test the induction target concentration of sevoflurane on the spikes wave occurrence.

Condition Intervention
General Anesthesia
Drug: Induction with Sevoflurane

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single Blind (Participant)
Primary Purpose: Prevention
Official Title: Interest of the Induction With Target-controlled Inhalation of Sevoflurane on Spikes Wave Occurrence

Resource links provided by NLM:

Further study details as provided by University Hospital, Bordeaux:

Primary Outcome Measures:
  • Incidence of spike wave [ Time Frame: during anaesthesia induction with sevoflurane ]

Enrollment: 34
Study Start Date: March 2006
Study Completion Date: July 2008
Primary Completion Date: July 2008 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: A
2.5% target concentration
Drug: Induction with Sevoflurane
Active Comparator: B
2.5% manually selected
Drug: Induction with Sevoflurane


Ages Eligible for Study:   18 Years to 60 Years   (Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • programmed gynecological surgery
  • ASA 1 or 2

Exclusion Criteria:

  • arterial hypertension
  • gastro-oesophageal reflux
  • pregnancy
  • diabetes
  • obesity
  • asthma
  • tobacco
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00775879

Sponsors and Collaborators
University Hospital, Bordeaux
Principal Investigator: Benjamin JULLIAC, Dr University Hospital, Bordeaux
  More Information

Responsible Party: University Hospital, Bordeaux Identifier: NCT00775879     History of Changes
Other Study ID Numbers: CHUBX 2004/01
Study First Received: October 17, 2008
Last Updated: May 17, 2013

Keywords provided by University Hospital, Bordeaux:
Général anesthesia

Additional relevant MeSH terms:
Platelet Aggregation Inhibitors
Anesthetics, Inhalation
Anesthetics, General
Central Nervous System Depressants
Physiological Effects of Drugs processed this record on April 26, 2017