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Mannheim Obesity Study (MOS)

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified March 2013 by Alexander Lammert, University Hospital Mannheim.
Recruitment status was:  Recruiting
Information provided by (Responsible Party):
Alexander Lammert, University Hospital Mannheim Identifier:
First received: October 8, 2008
Last updated: March 9, 2013
Last verified: March 2013

MOPS: Mannheim Obesity Pilot Study


Obesity is a central feature of the metabolic syndrome. With increasing prevalence of overweight and obesity, the incidence of WHO III° obesity will further augment. In this subset of obese patients, metabolic complications and cardiovascular risk are major clinical issues. Epidemiological data show that with increased BMI mortality rises (1). The SOS-Study demonstrated, for the first time, that bariatric surgery and consecutive weight reduction are associated with a decrease in cardiovascular and overall mortality. Significant mortality in this study was caused by cardiovascular events and cancer.

Metabolic Syndrome - MS - Despite varying definitions of the metabolic syndrome, obesity is one of its central features. Depending on the definition used, it can represent an obligate criterion (IDF) or a facultative parameter (WHO and ATP III). Even though not obligate, extreme obesity is a central risk factor for most other parameters of the metabolic syndrome.

Endothelial dysfunction -ED- represents the initial step of atherosclerosis (3). An appropriate measurement is the evaluation by retinal analysis. Epidemiological data demonstrate increased cardiovascular risk with retinal vessel pathology (4).


Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Mannheim Obesity Pilot Study: Evaluation of Metabolic Und Cardiovascular Risk in Obesity

Further study details as provided by Alexander Lammert, University Hospital Mannheim:

Primary Outcome Measures:
  • Metabolic syndrome [ Time Frame: baseline, after 1 and 2 years ]
  • Framingham risk score [ Time Frame: baseline, 1 and 2 years ]
  • Subclinical atherosclerosis (IMT) [ Time Frame: baseline, 1 and 2 years ]
  • Endothelial dysfunction [ Time Frame: baseline, 1 and 2 years ]

Secondary Outcome Measures:
  • Change in body weight [ Time Frame: baseline, 1 and 2 years ]

Estimated Enrollment: 120
Study Start Date: January 2005
Estimated Study Completion Date: January 2017
Estimated Primary Completion Date: January 2015 (Final data collection date for primary outcome measure)
Bariatric surgery
Bariatric surgery
conservative Therapie
diet and exercise

  Show Detailed Description


Ages Eligible for Study:   18 Years to 88 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
outpatient department of an university hospital

Inclusion Criteria:

  • obesity WHO I-III

Exclusion Criteria:

  • pregnancy
  • acute vascular event within the last 3 months
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00770276

Contact: Hans-Peter Hammes, MD +496213832663
Contact: Alexander Lammert +496213832317

University hospital of Mannheim Recruiting
Mannheim, BW, Germany, 68167
Contact: Hans-Peter Hammes, MD    +496213832663   
Principal Investigator: Alexander Lammert         
Principal Investigator: Petra Stuebler, MD         
Sponsors and Collaborators
Universitätsmedizin Mannheim
  More Information


Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Alexander Lammert, Dr. med., University Hospital Mannheim Identifier: NCT00770276     History of Changes
Other Study ID Numbers: MOS
Study First Received: October 8, 2008
Last Updated: March 9, 2013

Keywords provided by Alexander Lammert, University Hospital Mannheim:
obesity WHO I-III
metabolic syndrome
Framingham risk score
subclinical atherosclerosis
endothelial dysfunction

Additional relevant MeSH terms:
Nutrition Disorders
Body Weight
Signs and Symptoms processed this record on September 21, 2017