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Uremic Toxins in the Intensive Care Unit (ICU): Patients With Sepsis

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ClinicalTrials.gov Identifier: NCT00752245
Recruitment Status : Unknown
Verified June 2015 by University Hospital, Ghent.
Recruitment status was:  Recruiting
First Posted : September 15, 2008
Last Update Posted : June 3, 2015
Sponsor:
Information provided by (Responsible Party):
University Hospital, Ghent

Brief Summary:
Study of the kinetics of uremic toxins in the ICU patients with acute renal failure, in order to optimize the dialysis dose: patients with sepsis/multi-organ failure. The sampling of blood and dialysate will be done during dialyses with different durations (4, 6 and 8h)

Condition or disease Intervention/treatment Phase
Renal Failure Multi Organ Failure Procedure: Dialysis during 4 hours Procedure: Dialysis during 6 hours Procedure: Dialysis during 8 hours Not Applicable

Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 12 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Study of the Kinetics of Uremic Toxins in the ICU Patients With Acute Renal Failure, in Order to Optimize the Dialysis Dose: Patients With Sepsis/Multi-organ Failure
Study Start Date : September 2008
Estimated Primary Completion Date : December 2015
Estimated Study Completion Date : December 2015

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Sepsis
U.S. FDA Resources

Arm Intervention/treatment
Experimental: 1
Dialysis during 4 hours
Procedure: Dialysis during 4 hours
Blood and dialysate sampling
Active Comparator: 2
Dialysis during 6 hours
Procedure: Dialysis during 6 hours
Blood and dialysate sampling
Active Comparator: 3
Dialysis during 8 hours
Procedure: Dialysis during 8 hours
Blood and dialysate sampling



Primary Outcome Measures :
  1. Registration of toxin removal efficiency [ Time Frame: During dialysis ]


Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • ICU patients with sepsis/multi-organ failure with acute renal failure

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00752245


Contacts
Contact: Sunny Eloot, PhD Sunny.eloot@ugent.be

Locations
Belgium
University Hospital Ghent Recruiting
Ghent, Belgium, 9000
Principal Investigator: Raymond Vanholder, MD, PhD         
Sub-Investigator: Sunny Eloot, PhD         
Sponsors and Collaborators
University Hospital, Ghent
Investigators
Principal Investigator: Raymond Vanholder, MD, PhD University Hospital, Ghent

Additional Information:
Responsible Party: University Hospital, Ghent
ClinicalTrials.gov Identifier: NCT00752245     History of Changes
Other Study ID Numbers: 2008/373
First Posted: September 15, 2008    Key Record Dates
Last Update Posted: June 3, 2015
Last Verified: June 2015

Keywords provided by University Hospital, Ghent:
ICU patients with acute renal failure with sepsis/multi-organ failure

Additional relevant MeSH terms:
Sepsis
Renal Insufficiency
Acute Kidney Injury
Multiple Organ Failure
Infection
Systemic Inflammatory Response Syndrome
Inflammation
Pathologic Processes
Kidney Diseases
Urologic Diseases
Shock