Biodistribution of Neutrophile Proteases in the Sputum of Patients Affected by Cystic Fibrosis (Pro-Muco)
The purpose of the proposed project is to characterize the neutrophile proteases which participate in the chronic inflammatory phenomenon associated with the cystic fibrosis and which are responsible for the degradation of the lung tissue.
The respiratory failure which results from it is one of main causes of the fatal evolution of this pathology but the anti-inflammatory therapies based on the use of antiproteases targeting specifically the soluble elastase did not end, until now, in the hoped results.
The identification of the other noxious targets is a crucial element to give new orientations to the anti-inflammatory strategies based on the administration of antiproteases which remain a promising way.
|Study Design:||Observational Model: Case-Control
Time Perspective: Prospective
|Official Title:||Study of the Biodistribution of PMN Serine Proteases in Sputum of Patients Affected by Cystic Fibrosis: Towards New Anti-inflammatory Therapies|
|Study Start Date:||January 2008|
|Study Completion Date:||January 2012|
|Primary Completion Date:||January 2012 (Final data collection date for primary outcome measure)|
Minor with cystic fibrosis
Adult with cystic fibrosis
Please refer to this study by its ClinicalTrials.gov identifier: NCT00750932
|CHRU de Tours|
|Tours, France, 37044|
|Principal Investigator:||Patrice DIOT, PHD||Tours Hospital|