Neutrophil Gelatinase-associated Lipocalin Concentration in Coronary Artery Disease

This study has been completed.
Information provided by:
Cardiovascular Research Society, Greece Identifier:
First received: September 8, 2008
Last updated: July 7, 2010
Last verified: August 2009
Serum NGAL has been described as a biomarker of neutrophil activation and an inflammatory marker which correlates to obesity and its metabolic complications. Since neutrophil activation has been implicated in the pathogenesis of coronary artery disease, the investigators hypothesized that serum NGAL levels would be higher in patients with CAD and that serum concentration would correlate with the extent of CAD as documented by coronary angiography, serving as a potential biomarker of the severity of CAD.

Coronary Artery Disease

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Neutrophil Gelatinase-associated Disease: a Potential Biomarker of the Severity of Coronary Artery Disease

Resource links provided by NLM:

Further study details as provided by Cardiovascular Research Society, Greece:

Biospecimen Retention:   Samples Without DNA

Enrollment: 73
Study Start Date: September 2008
Study Completion Date: September 2009
Primary Completion Date: March 2009 (Final data collection date for primary outcome measure)
Patients with angiographically confirmed significant CAD
Patients without significant CAD

Detailed Description:

Inflammation is considered to play a major role in coronary artery disease (CAD) which accounts for high morbidity and mortality rates in the western world. Several lines of evidence support a role for neutrophils in the development of atherosclerosis and its progression.

Neutrophil gelatinase-associated lipocalin (NGAL), also known as Lipocalin-2, is a 25-kDa secretory glycoprotein that was originally identified in mouse kidney cells and human neutrophil granules. This protein has been used as a marker of neutrophil activation in several studies, while recently it was found to be an inflammatory marker closely related to obesity and its metabolic complications.

Recently, lactoferrin, a protein which co-localizes with NGAL in the specific granules of human neutrophils has been proposed as a more dynamic marker of neutrophil activation compared to the widely used myeloperoxidase in patients with CAD.

In line with the accumulating evidence, this study is designed to investigate the relationship between serum NGAL concentration and the presence or the severity of coronary artery disease according to coronary angiography.


Ages Eligible for Study:   18 Years to 85 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients admitted for coronary angiography.

Inclusion Criteria:

  • Consenting patients undergoing coronary angiography due to suspected CAD based on clinical history and results from non-invasive testing

Exclusion Criteria:

  • Abnormal renal function
  • Any known active inflammatory disease
  • Receiving medical therapy with antibiotics, corticosteroids, immunosuppressive agents
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Please refer to this study by its identifier: NCT00749281

Athens Euroclinic
Athens, Attica, Greece, 11521
Sponsors and Collaborators
Cardiovascular Research Society, Greece
Study Chair: Demosthenes Katritsis, MD,PhD Athens Euroclinic and Cardiovascular Research Society
  More Information

No publications provided

Responsible Party: Department of Cardiology, Athens Euroclinic Identifier: NCT00749281     History of Changes
Other Study ID Numbers:
Study First Received: September 8, 2008
Last Updated: July 7, 2010
Health Authority: Greece: Ethics Committee

Keywords provided by Cardiovascular Research Society, Greece:
coronary artery disease

Additional relevant MeSH terms:
Coronary Artery Disease
Coronary Disease
Myocardial Ischemia
Arterial Occlusive Diseases
Cardiovascular Diseases
Heart Diseases
Vascular Diseases processed this record on November 24, 2015