Assessment of Cytokine Values in Serum and by RT-PCR in HIV-1 Individuals With and Without HAART
![]() |
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. |
ClinicalTrials.gov Identifier: NCT00746473 |
Recruitment Status
:
Completed
First Posted
: September 4, 2008
Last Update Posted
: September 4, 2008
|
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
Condition or disease |
---|
HIV Infections |
Study Type : | Observational |
Actual Enrollment : | 73 participants |
Observational Model: | Cohort |
Time Perspective: | Prospective |
Official Title: | Assessment of Cytokine Values in Serum and by Specific cDNA Amplification and Detection Using RT-PCR in HIV-1 Infected Individuals With and Without Highly Active Anti-Retroviral Therapy (HAART) |
Study Start Date : | August 2004 |
Actual Study Completion Date : | October 2005 |

Group/Cohort |
---|
1
15 HIV-1 infected individuals, with or without AIDS, who had never received ARV. These patients had not yet been indicated for ARV, or had had HIV-1 infection diagnosed a few days before inclusion in this study.
|
2
27 HIV-1 infected individuals, sick or not, on ARV treatment, five with two nucleoside/nucleotide reverse transcriptase inhibitors (NRTI) and one nonnucleoside reverse transcriptase inhibitor (NNRTI), and 22 on HAART with two NRTI, or one NRTI and one NNRTI, and one protease inhibitor (PI), and VL equal to or greater than 50 copies of plasma RNA/mL. Treatment duration in this group varied between three and 145 months (mean 53.62 months; median 42 months). |
3
31 HIV-1 infected individuals on ARV treatment, 16 on HAART with two NRTI, or one NRTI and one NNRTI, and one PI, and 15 with two NRTI and one NNRTI. All G3 patients had undetectable VL for at least the past 6 months. Treatment in this group varied between five to 108 months (mean 48.13 months; median 42 months).
|
4
20 blood donors without clinical complaints and negative for anti-HIV-1/2 antibodies. None of them showed any sign of disease.
|

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
Ages Eligible for Study: | 22 Years to 66 Years (Adult, Senior) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
Inclusion Criteria:
- HIV infection
Exclusion Criteria:
- no HIV infection

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00746473
Brazil | |
SAE e Hospital Dia de Aids | |
Botucatu, São Paulo, Brazil |
Principal Investigator: | Domingos A Meira, PhD, MD | Faculdade de Medicina de Botucatu - Unesp |
Responsible Party: | Sergio Muller, Faculdade de Medicina de Botucatu - Unesp |
ClinicalTrials.gov Identifier: | NCT00746473 History of Changes |
Other Study ID Numbers: |
upeclin/HC/FMB-Unesp-12 |
First Posted: | September 4, 2008 Key Record Dates |
Last Update Posted: | September 4, 2008 |
Last Verified: | September 2008 |
Additional relevant MeSH terms:
HIV Infections Lentivirus Infections Retroviridae Infections RNA Virus Infections Virus Diseases |
Sexually Transmitted Diseases, Viral Sexually Transmitted Diseases Immunologic Deficiency Syndromes Immune System Diseases |