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Oxidative Stress in Critical Ill Patients in Surgical Intensive Care Unit

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified August 2009 by National Taiwan University Hospital.
Recruitment status was:  Recruiting
Information provided by:
National Taiwan University Hospital Identifier:
First received: September 2, 2008
Last updated: September 4, 2009
Last verified: August 2009

In clinical practice, the oxidative stress is related to circulatory shock, sepsis, acute lung injury, and acute respiratory distress syndrome. There are some questions on the oxidative stress of the critical illness. First, the investigators want to search out the effects of the past history, smoking, alcohol drinking, use of antioxidants, different diseases, and different duration of SIRS on the degree of oxidative stress. Second, besides total count of ROS, the investigators used new techniques to determine superoxide(O2●-), hydrogen peroxide (H2O2), and hypochlorous acid(HOCl). Furthermore, we want to investigate the correlation of the degree of different reactive oxygen species and the severity of SIRS or shock. Third, we try to investigate the correlation between the change of oxidative stress and the prognosis of the patients.

The investigators wish this study will help them to investigate the effect of oxidative stress on critical ill patients, to modulate the oxidative stress, to decrease the occurrence of SIRS, shock, and multiorgan failure, and to improve the long term outcome of patients.

Condition Intervention Phase
Other: Chemiluminescence Analyzer
Phase 3

Study Type: Observational
Study Design: Time Perspective: Prospective
Official Title: Oxidative Stress in Critical Ill Patients in Surgical Intensive Care Unit

Further study details as provided by National Taiwan University Hospital:

Primary Outcome Measures:
  • 28-day Survival [ Time Frame: 28 days ]

Secondary Outcome Measures:
  • Days stay in ICU Days on ventilator SOFA score Complications [ Time Frame: 28 days ]

Biospecimen Retention:   Samples Without DNA
blood sample

Estimated Enrollment: 200
Study Start Date: May 2007
Groups/Cohorts Assigned Interventions
age > 18 y/o Patients admitted to surgical ICU
Other: Chemiluminescence Analyzer
measure reactive oxygen species


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Patients admitted to surgical ICU

Inclusion Criteria:

  • Age > 18 y/o
  • Admitted to surgical ICU

Exclusion Criteria:

  • Patients with brain death
  Contacts and Locations
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Please refer to this study by its identifier: NCT00745888

Contact: Yu-Chang Yeh, MD 886-9-68661829

National Taiwan University Hospital Recruiting
Taipei, Taiwan, 100
Contact: Yu-Chang Yeh, MD    886-9-68661829   
Principal Investigator: Yu-Chang Yeh, MD         
Sponsors and Collaborators
National Taiwan University Hospital
Principal Investigator: Yu-Chang Yeh National Taiwan University Hospital
  More Information

Responsible Party: Yu-Chang Yeh, National Taiwan University Hospital Identifier: NCT00745888     History of Changes
Other Study ID Numbers: 9561709132
Study First Received: September 2, 2008
Last Updated: September 4, 2009

Keywords provided by National Taiwan University Hospital:
oxidative stress
intensive care
Postoperative intensive care processed this record on May 25, 2017