Validation of HC250 and HC240 Series.

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00739011
Recruitment Status : Completed
First Posted : August 21, 2008
Last Update Posted : December 9, 2008
Information provided by:
Fisher and Paykel Healthcare

Brief Summary:
This study is designed to determine the effectiveness of two different CPAP devices. One a standard CPAP which has the ability to store comprehensive compliance and efficacy data and the second a auto adjusting CPAP which uses the energy spectrum analysis of flow signals to automatically adjust CPAP pressure and improve sleep variables.

Condition or disease Intervention/treatment Phase
Obstructive Sleep Apnea (OSA) Device: SleepStyle 254/244 CPAP series CPAP humidifier Not Applicable

Detailed Description:

All patients with suspected obstructive sleep apnea presenting at the Auckland Hospital Sleep Laboratory and referred for either a split-night or full night diagnostic study, will be offered participation in the study and will be recruited. From these patients, a total of 20 patients that are diagnosed with clinical obstructive sleep apnea syndrome, based on diagnostic polysomnography, will undergo titration with the HC254 Auto CPAP. An additional 20 patients will undergo titration with the HC244 CPAP.

The sleep physiologist evaluating the patient clinically will approach patients for participation in this study during their sleep laboratory visit. Consenting patients will undergo either an initial full night diagnostic polysomnography or a split night study as determined by the physician based on clinical requirements. Patients diagnosed with obstructive sleep apnea (AHI > 15/hr) during this diagnostic component will then undergo one of the following:

  • Treatment with the HC254 Auto CPAP during the second half of the study.
  • Treatment with the HC244 CPAP during the second half of the study.

The sleep physiologist will then determine final CPAP prescriptions for all patients based on the patient's response to CPAP therapy.

5 subjects who have completed the HC254 arm of the study will be brought back to the sleep lab for an additional PSG or partial PSG while on CPAP pressure set to 90th percentile pressure determined on the diagnostic night.

Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 40 participants
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Validation of Customer Requirements for the HC244/HC254
Study Start Date : August 2008
Actual Primary Completion Date : November 2008
Actual Study Completion Date : November 2008

Resource links provided by the National Library of Medicine

Arm Intervention/treatment
Experimental: 1 Device: SleepStyle 254/244 CPAP series CPAP humidifier
Therapeutic CPAP pressure will be determined for individual subjects during the titration portion of an overnight sleep study. This pressure will range from 4 to 20 cmH20

Primary Outcome Measures :
  1. Apnea Hypopnea Index (AHI) [ Time Frame: At the end of the sleep study ]

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusions criteria:

  • AHI > 15 on the diagnostic night or portion of the split night study.
  • ≥18yrs of age

Exclusion criteria:

  • Significant Central Apnea
  • CHF
  • Co-existing obesity related hypoventilation
  • Inability to give informed consent
  • Patient intolerance to CPAP
  • Anatomical or physiological conditions making CPAP therapy inappropriate.
  • Less than 3 hours in the titration period
  • Under Land Transport New Zealand (LTNZ) investigation

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00739011

New Zealand
Auckland Hospital Sleep laboratory
Auckland, New Zealand
Auckland Physiology Sleep Lab
Auckland, New Zealand
Sponsors and Collaborators
Fisher and Paykel Healthcare
Principal Investigator: Jessica Hayward, MSc Fisher and Paykel Healthcare

Responsible Party: Jessica Hayward, Fisher and Paykel Healthcare Identifier: NCT00739011     History of Changes
Other Study ID Numbers: FPHC240/250Val
First Posted: August 21, 2008    Key Record Dates
Last Update Posted: December 9, 2008
Last Verified: December 2008

Additional relevant MeSH terms:
Sleep Apnea, Obstructive
Sleep Apnea Syndromes
Respiration Disorders
Respiratory Tract Diseases
Sleep Disorders, Intrinsic
Sleep Wake Disorders
Nervous System Diseases