Micro Ribonucleic Acid (RNA) as Cholinergic Tone and Inflammatory Regulator in Inflammatory Bowel Disease
![]() |
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. |
ClinicalTrials.gov Identifier: NCT00734331 |
Recruitment Status :
Completed
First Posted : August 14, 2008
Last Update Posted : June 16, 2020
|
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
There is a reciprocal relationship between the central nervous system and the immune system. Stimulation of the vagus nerve results in secretion of acetylcholine (Ach) which decreases secretion of pro-inflammatory cytokines. Acetylcholine esterase is an enzyme that neutralizes Ach and thus, involves in regulation of Ach levels, and in the cholinergic tone and inflammatory state.
MicroRNAs (miRs) are evolutionarily conserved, RNAs that regulate gene expression. The investigators hypothesized that miRs controlling systemic communication processes function in one tissue in response to signals (i.e. neuronal, hormonal or others) from another.
Specifically, the investigators hypothesized that miRs control the inflammatory response in inflammatory bowel diseases through regulation of expression of messenger RNA of AchE.
Condition or disease |
---|
Inflammatory Bowel Disease |
Study Type : | Observational |
Actual Enrollment : | 40 participants |
Observational Model: | Case-Control |
Time Perspective: | Prospective |
Actual Study Start Date : | September 2008 |
Actual Primary Completion Date : | September 2009 |
Actual Study Completion Date : | September 2009 |
Group/Cohort |
---|
IBD
Inflammatory bowel disease patients
|
Control
Average risk patients undergoing screening colonoscopy
|
- Elevated expression of specific micro RNAs that regulate the expression of the enzyme Acetylcholine esterase in inflammatory bowel disease patients compared to healthy controls. [ Time Frame: one year ]
- A statistically significant relation between micro RNA expression and disease activity and inflammatory indices [ Time Frame: one year ]
Biospecimen Retention: Samples With DNA

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
Ages Eligible for Study: | 18 Years to 75 Years (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
Inclusion Criteria:
- Inflammatory bowel disease patients under going colonoscopy
Exclusion Criteria:
- Debilitated patients who need an apotropsy
- Age < 18 or age > 75
- Pregnant women
- Evidence of previous or current cancer
- Inflammatory disease other than IBD

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00734331
Israel | |
Tel Aviv Sourasky Medical Center | |
Tel Aviv, Israel |
Responsible Party: | michal roll, MicroRNA-132 Modulates Cholinergic Signaling and Inflammation in Human Inflammatory Bowel Disease, Tel-Aviv Sourasky Medical Center |
ClinicalTrials.gov Identifier: | NCT00734331 |
Other Study ID Numbers: |
TASMC-08-NM-300-CTIL |
First Posted: | August 14, 2008 Key Record Dates |
Last Update Posted: | June 16, 2020 |
Last Verified: | June 2020 |
inflammatory bowel disease micro RNA cholinergic tone inflammation |
Intestinal Diseases Inflammatory Bowel Diseases Gastrointestinal Diseases Digestive System Diseases Gastroenteritis |