Micro Ribonucleic Acid (RNA) as Cholinergic Tone and Inflammatory Regulator in Inflammatory Bowel Disease
|ClinicalTrials.gov Identifier: NCT00734331|
Recruitment Status : Unknown
Verified August 2008 by Tel-Aviv Sourasky Medical Center.
Recruitment status was: Not yet recruiting
First Posted : August 14, 2008
Last Update Posted : August 14, 2008
There is a reciprocal relationship between the central nervous system and the immune system. Stimulation of the vagus nerve results in secretion of acetylcholine (Ach) which decreases secretion of pro-inflammatory cytokines. Acetylcholine esterase is an enzyme that neutralizes Ach and thus, involves in regulation of Ach levels, and in the cholinergic tone and inflammatory state.
MicroRNAs (miRs) are evolutionarily conserved, RNAs that regulate gene expression. The investigators hypothesized that miRs controlling systemic communication processes function in one tissue in response to signals (i.e. neuronal, hormonal or others) from another.
Specifically, the investigators hypothesized that miRs control the inflammatory response in inflammatory bowel diseases through regulation of expression of messenger RNA of AchE.
|Condition or disease|
|Inflammatory Bowel Disease|
|Study Type :||Observational|
|Estimated Enrollment :||40 participants|
|Observational Model:||Case Control|
|Study Start Date :||September 2008|
|Estimated Primary Completion Date :||September 2009|
|Estimated Study Completion Date :||September 2009|
Inflammatory bowel disease patients
Average risk patients undergoing screening colonoscopy
- Elevated expression of specific micro RNAs that regulate the expression of the enzyme Acetylcholine esterase in inflammatory bowel disease patients compared to healthy controls. [ Time Frame: one year ]
- A statistically significant relation between micro RNA expression and disease activity and inflammatory indices [ Time Frame: one year ]
Biospecimen Retention: Samples With DNA
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00734331
|Contact: Nitsan Maharshak, MDfirstname.lastname@example.org|
|Tel Aviv Sourasky Medical Center||Not yet recruiting|
|Tel Aviv, Israel|
|Principal Investigator: Nitsan Maharshak, MD|