Primary Outcome Measures:
- Defining the neurophysiological conditions that are necessary for conscious experience. [ Time Frame: Immediate ]
Secondary Outcome Measures:
- Understanding the neurophysiological correlates of conditions associated with restricted conscious experience such as sedation and anesthesia. [ Time Frame: Immediate ]
In the proposed experiments cortical areas will be stimulated using low frequency, low-amplitude transcranial magnetic stimulation (TMS) in healthy human subjects during wakefulness and during drug-induced responsive sedation and unresponsive sedation. Simultaneously, high-density electroencephalography (Hd-EEG) will be recorded to evaluate the temporal and spatial characteristics of evoked responses and induced rhythms over the cortex.