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Association Study of Gene Polymorphisms With Cardiac Performance

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified August 2008 by University Hospital, Essen.
Recruitment status was:  Recruiting
Information provided by:
University Hospital, Essen Identifier:
First received: August 4, 2008
Last updated: NA
Last verified: August 2008
History: No changes posted
The purpose of this study is to determine whether polymorphisms in G protein subunits, namely Galphas and Galphaq, are associated with altered cardiac performance in heart failure patients.

Genetic Polymorphism Coronary Artery Disease Hemodynamics

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Observational Association Study of G Protein Polymorphisms With Cardiac Performance in Coronary Artery Disease Patients Undergoing Coronary Artery Bypass Grafting

Further study details as provided by University Hospital, Essen:

Primary Outcome Measures:
  • genotype dependent change of hemodynamic variables [ Time Frame: one day ]

Secondary Outcome Measures:
  • all cause mortality [ Time Frame: 60 days ]

Biospecimen Retention:   Samples With DNA
whole blood

Estimated Enrollment: 500
Study Start Date: May 2008
Estimated Study Completion Date: June 2011
Estimated Primary Completion Date: January 2011 (Final data collection date for primary outcome measure)
Detailed Description:
G Protein pathways plays a pivotal role in mediating positive inotropy and cardiac hypertrophy by transducing signals of neurohormones in cardiomyocytes. Single nucleotide polymorphisms (SNPs) in the G protein subunits Galphas and Galphaq have been shown to result in altered protein expression. We now want to examine whether G Protein polymorphisms alter NYHA functional class, and hemodynamic variables in patients with coronary artery disease scheduled for coronary artery bypass grafting .

Ages Eligible for Study:   18 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients with coronary artery disease scheduled for coronary artery bypass grafting in the university hospital

Inclusion Criteria:

  • clinical diagnosis of coronary artery disease
  • patients scheduled for coronary artery bypass grafting

Exclusion Criteria:

  • emergency operation
  • combined vitium
  Contacts and Locations
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Please refer to this study by its identifier: NCT00730899

Contact: Ulrich H Frey, MD +49201723 ext 1401

University Hospital Recruiting
Essen, Nordrhein-Westfalen, Germany, 45147
Contact: Ulrich H Frey, MD    +49201723 ext 1401   
Principal Investigator: Jürgen Peters, MD         
Sponsors and Collaborators
University Hospital, Essen
Study Director: Jürgen Peters, MD University Hospital, Essen
  More Information

Additional Information:
Responsible Party: Ulrich Frey, University Hospital Essen Identifier: NCT00730899     History of Changes
Other Study ID Numbers: HOT-001
Study First Received: August 4, 2008
Last Updated: August 4, 2008

Additional relevant MeSH terms:
Coronary Artery Disease
Myocardial Ischemia
Coronary Disease
Heart Diseases
Cardiovascular Diseases
Arterial Occlusive Diseases
Vascular Diseases processed this record on August 22, 2017