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Explore the Nature Factors Relevant to Learning-Pioneering Natural Factors That Influences Science Learning II

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified December 2010 by National Taiwan University Hospital.
Recruitment status was:  Recruiting
Information provided by:
National Taiwan University Hospital Identifier:
First received: July 9, 2008
Last updated: December 10, 2010
Last verified: December 2010

Genetic research has provided the most exciting breakthroughs in neuroscience and cognitive science. Partially genetically determined cognitive impairments have been described in people with COMT, 5HT6, BDNF (Swillen et al., 2000; Moss et al., 1999, Henry et al., 2002, Bilder et al., 2002)and biological systemic pathway candidate genes.

Selective inhibitors of COMT proved to improve cognitive function in animals and in patients with Parkinson's disease (Carlsson, et al, 2000). Recent studies suggested that variation in COMT activity might have neurobiological effects specific to the prefrontal cortex; the COMT (Val) allele with high activity impairs tasks of prefrontal cognition in people with schizophrenia (Egan et al., 2001) and higher loading of the COMT (Met) allele is associated with better cognitive performance on attention and processing speed in people with chronic schizophrenia (Bilder et al., 2002). Moreover, prefrontal dopamine levels are increased in COMT knockout mouse model (Gogos et al., 1998). This suggests that in people who have heterozygosis on COMT, dopamine levels could be abnormal. Thus, variation in COMT expression could also affect performance on prefrontal cognitive tasks. In the previous study, we found the neuropsychological profile in students with COMT (Met) allele is better in object perception, problem solving and planning, and abstract and social thinking (Henry et al., 2002).

5-HT6 inhibitor has been reported to raise extracellular acetylcholine levels in the cortex and hippocampus (Dawson et al., 2001 and Riemer et al., 2003). Acetylcholine release in hippocampal and cortical regions is known to be important for memory acquisition and retention, and several groups have demonstrated that 5-HT6 blockade overcomes scopolamine-induced amnesia. We hypothesize that variations in COMT and 5-HT6 are associated with genotype that will cause a poor/better performance in cognitive tasks.

With the aim to establish the possible correlation between candidate genes (COMT, 5HT6,BDNF and biological systemic pathway candidate genes. etc) and cognitive ability, which will provide us an understanding on factors and its extent that affect students' thinking, and then develop appropriate teaching models or strategies for assisting students in learning. It seems timely, therefore, to consider how we might implement our increased understanding of brain development and brain function to explore educational questions.


Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Retrospective
Official Title: the Cognitive Ability Dose Associate With COMT, 5HT6, BDNF and Biological Systemic Pathway Candidate Genes in General Population

Further study details as provided by National Taiwan University Hospital:

Primary Outcome Measures:
  • observational studies, related to core objectives of the study and learning. [ Time Frame: at least five years follow ]

Estimated Enrollment: 2800
Study Start Date: August 2006
Estimated Primary Completion Date: July 2012 (Final data collection date for primary outcome measure)

  Show Detailed Description


Ages Eligible for Study:   16 Years to 65 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
Taiwan genernal population

Inclusion Criteria:

  • Healthy volunteers with inform concern
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00713570

Contact: Chung-Yi Hu, PhD 886-2-23123456 ext 66914
Contact: Chun-Yen Chang, PhD 886-2-29354393

Chung-Yi Hu Recruiting
Taipei, Taiwan
Contact: Chung Yi Hu, PhD    886-2-23123456 ext 66914   
Contact: Chun-Yeh Chanf, PhD    886-2-29354393   
Principal Investigator: Chun Yen Chang, PhD         
Sponsors and Collaborators
National Taiwan University Hospital
Principal Investigator: Chung Yi Hu, PhD Department of Clinical Laboratory Sciences and Medical Biotechonology
Principal Investigator: Chun-Yen Chang, PhD Professor of Department of Earth Sciences Director of Science Education Center,PI of Building the e-Learning Research Teams for Excellence National Taiwan Normal University
Principal Investigator: Ting-Chi Yeh, MD Division of Pediatric Hematology-Oncology, Mackay Memorial Hospital
  More Information

Responsible Party: National Taiwan University Hospital Research Ethics Committee, National Taiwan University Hospital Identifier: NCT00713570     History of Changes
Other Study ID Numbers: 200612069R
Study First Received: July 9, 2008
Last Updated: December 10, 2010

Keywords provided by National Taiwan University Hospital:
intellectual functioning
memory,visual-spatial and perceptual functions
cognitive abilities
neuron biological systemic pathway candidate genes
Healthy subjects processed this record on September 21, 2017