Speech and Language Therapy After Stroke

This study has been terminated.
(Protocol expired; PI retired)
Rehabilitation Institute of Chicago
Information provided by (Responsible Party):
University of Chicago
ClinicalTrials.gov Identifier:
First received: July 9, 2008
Last updated: June 10, 2013
Last verified: June 2013

Our overall goal is to advance the state of functional brain imaging in aphasia, and then to apply the method to an intensive, imitation-based treatment for non-fluent aphasia.

Condition Intervention
Ischemic Stroke
Behavioral: Imitate Therapy

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Double Blind (Subject, Outcomes Assessor)
Primary Purpose: Treatment
Official Title: Neurophysiological Measurement in Aphasia Treatment

Resource links provided by NLM:

Further study details as provided by University of Chicago:

Primary Outcome Measures:
  • Changes in scores on Western Aphasia Battery [ Time Frame: Four months ] [ Designated as safety issue: No ]

Enrollment: 34
Study Start Date: August 2007
Study Completion Date: January 2012
Primary Completion Date: January 2012 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Experimental
Computer-based Aphasia therapy
Behavioral: Imitate Therapy
Imitation-based computer therapy
Other Name: Imitate
Active Comparator: Control
Control Arm - Healthy subjects.
Behavioral: Imitate Therapy
Imitation-based computer therapy
Other Name: Imitate

Detailed Description:

Detailed information will follow in the next progress report.


Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  1. Single ischemic infarction in the MCA territory involving the cerebral cortex (confirmed by CT or MRI)
  2. Aphasia
  3. Visual attention and language comprehension sufficient to perform imitation fMRI tasks
  4. Right handed (prior to stroke)

Exclusion Criteria:

Exclusions to the study are people with cardiac pacemakers, claustrophobia, neurosurgical clips, or cognitive impairments too severe to permit cooperation with cognitive tasks in an MRI scanner.

  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00713050

United States, California
Solodkin/Small Brain Circuits Laboratory
Irvine, California, United States, 92697
University of California Irvine
Irvine, California, United States, 92697
Sponsors and Collaborators
University of Chicago
Rehabilitation Institute of Chicago
Principal Investigator: Steven Small, M.D., Ph.D. University of Chicago
  More Information

No publications provided

Responsible Party: University of Chicago
ClinicalTrials.gov Identifier: NCT00713050     History of Changes
Other Study ID Numbers: 13785A, 5R01DC007488-05
Study First Received: July 9, 2008
Last Updated: June 10, 2013
Health Authority: United States: Federal Government

Keywords provided by University of Chicago:
mirror neuron

ClinicalTrials.gov processed this record on August 26, 2015