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The Longevity Genes in Founder Populations Project

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ClinicalTrials.gov Identifier: NCT00707694
Recruitment Status : Recruiting
First Posted : July 1, 2008
Last Update Posted : March 16, 2021
Sponsor:
Collaborator:
National Institutes of Health (NIH)
Information provided by (Responsible Party):
Albert Einstein College of Medicine

Brief Summary:
We believe extreme longevity is due to specific genes which function to delay aging and prevent disease. The purpose of our research is to identify the genes/mutations associated with healthier aging; to understand the biological functions of these genes/mutations; and to develop therapies to replicate these preservative genetic activities in individuals who do not have the genetic profile for longevity.

Condition or disease
Extreme Longevity

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Study Type : Observational
Estimated Enrollment : 1500 participants
Observational Model: Case-Control
Time Perspective: Prospective
Official Title: Searching for Longevity Genes in the Historically Unique Ashkenazi Jewish Population
Actual Study Start Date : July 1998
Estimated Primary Completion Date : October 2021
Estimated Study Completion Date : October 2021

Resource links provided by the National Library of Medicine


Group/Cohort
Probands
Ashkenazi Jews ages 95 and older
Offspring
Ashkenazi Jewish offspring of Ashkenazi Jewish parent(s) who lived to at least the age of 95
Controls
Ashkenazi Jewish people with no family history of longevity




Information from the National Library of Medicine

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Ages Eligible for Study:   65 Years and older   (Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

Ashkenazi Jews:

Ages 95 and older, their offspring and control group with no family history of longevity.

Criteria

Inclusion Criteria:

  • Ashkenazi Jewish, age 95+,
  • Offspring of person age 95+,
  • Offspring of parents who died age 70 or younger.

Exclusion Criteria:

  • Non-Ashkenazis

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00707694


Contacts
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Contact: Deborah Davidson, MBA 718-430-3237 longevity@aecom.yu.edu

Locations
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United States, Massachusetts
Boston University Medical Center Recruiting
Boston, Massachusetts, United States, 02118-2526
Contact: Thomas Perls, MD, MPH    617-638-7207      
United States, New York
Weill Cornell Medical College Recruiting
New York, New York, United States, 10065
Contact: Todd Evans, MD    646-962-8200      
Private Homes Recruiting
New York, New York, United States
Contact: Deborah Davidson, MBA    718-430-3237    longevity@aecom.yu.edu   
Hebrew Home Riverdale Recruiting
Riverdale, New York, United States, 10471
Contact: Charlotte Dell, LMSW    718-581-1139      
Sponsors and Collaborators
Albert Einstein College of Medicine
National Institutes of Health (NIH)
Investigators
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Principal Investigator: Nir Barzilai, MD Albert Einstein College of Medicine
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
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Responsible Party: Albert Einstein College of Medicine
ClinicalTrials.gov Identifier: NCT00707694    
Other Study ID Numbers: 1998-125
First Posted: July 1, 2008    Key Record Dates
Last Update Posted: March 16, 2021
Last Verified: October 2020
Keywords provided by Albert Einstein College of Medicine:
95 years of age and older