Exercise Training Improves Coronary Endothelial Dysfunction in Diabetes Mellitus Type 2 and Coronary Artery Disease
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ClinicalTrials.gov Identifier: NCT00693537 |
Recruitment Status
:
Completed
First Posted
: June 9, 2008
Last Update Posted
: June 9, 2008
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Condition or disease | Intervention/treatment | Phase |
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Type 2 Diabetes Mellitus Coronary Artery Disease | Procedure: Coronary angiography Behavioral: Exercise training | Phase 4 |
Study Type : | Interventional (Clinical Trial) |
Allocation: | Randomized |
Official Title: | Long- But Not Short-Term Exercise Training Improves Coronary Endothelial Dysfunction in Diabetes Mellitus Type 2 and Coronary Artery Disease |

Arm | Intervention/treatment |
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Experimental: A
4 weeks in-hospital exercise training (6x15 min bicycle/day, 5 days/week) followed by a 5 months ambulatory exercise program (30 min ergometer/day, 5 days/week, plus 1h group exercise/week)
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Procedure: Coronary angiography
At baseline, 4 weeks, and 6 months changes in diameter of coronary arteries in response to intracoronary infusion of acetylcholine were analyzed by quantitative coronary angiography, mean peak flow velocity by Doppler velocimetry, and intramural plaques by intravascular ultrasound.
Behavioral: Exercise training
4 weeks in-hospital exercise training (6x15 min bicycle/day, 5 days/week) followed by a 5 months ambulatory exercise program (30 min ergometer/day, 5 days/week, plus 1h group exercise/week)
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No Intervention: B
Control
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Procedure: Coronary angiography
At baseline, 4 weeks, and 6 months changes in diameter of coronary arteries in response to intracoronary infusion of acetylcholine were analyzed by quantitative coronary angiography, mean peak flow velocity by Doppler velocimetry, and intramural plaques by intravascular ultrasound.
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Ages Eligible for Study: | 50 Years to 80 Years (Adult, Senior) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- written informed consent
- preserved left ventricular function (left ventricular ejection fraction ≥ 50%)
- a physical work capacity ≥ 50 W
- at least one significant coronary stenosis > 50%, whereas either the left anterior descending (LAD) or circumflex artery (RCX) has to be free from disease or stenoses ≤ 25% for the assessment of intracoronary flow measurements
Exclusion Criteria:
- diseases further affecting endothelial function
- untreated hypertension (systolic blood pressure > 160 mm Hg or a diastolic blood pressure of > 90 mm Hg)
- cigarette smoking during the previous six months
- LDL-cholesterol > 4.3 mmol/l
- ventricular tachyarrhythmias
- chronic obstructive pulmonary disease
- severe renal or hepatic dysfunction
- valvular heart disease
- myocardial infarction within the previous 4 weeks

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00693537
Austria | |
University Institute of Sports Medicine, Prevention and Rehabilitation | |
Salzburg, Austria, 5020 |
ClinicalTrials.gov Identifier: | NCT00693537 History of Changes |
Other Study ID Numbers: |
UISM-2-2008 |
First Posted: | June 9, 2008 Key Record Dates |
Last Update Posted: | June 9, 2008 |
Last Verified: | June 2008 |
Additional relevant MeSH terms:
Diabetes Mellitus Diabetes Mellitus, Type 2 Coronary Artery Disease Myocardial Ischemia Coronary Disease Glucose Metabolism Disorders Metabolic Diseases |
Endocrine System Diseases Heart Diseases Cardiovascular Diseases Arteriosclerosis Arterial Occlusive Diseases Vascular Diseases |