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Airway Dysfunction and Remodelling in Athletes Following Swimming Training in Chlorinated Pools (proto nage)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00686452
Recruitment Status : Unknown
Verified May 2008 by Laval University.
Recruitment status was:  Recruiting
First Posted : May 29, 2008
Last Update Posted : December 22, 2008
Information provided by:
Laval University

Brief Summary:

Swimmers show the highest prevalence of asthma among elite athletes, certainly due to chlorine exposure. The consequences of a chronic exposure to chlorine compounds by swimmers and the mechanisms of asthme in this population are still poorly documented. Specific diagnostic criteria have been proposed by the International Olympic Committee - Medical Council (IOC-MC) and World anti-doping agency (WADA) to determine the presence of asthma in athletes. Using the more specific bronchial provocation tests, our aims are

  1. to compare the prevalence of asthma in swimmers and control subjects
  2. to analyze the Influence of chlorine exposure on bronchial inflammatory processes in swimmers versus control subjects
  3. to study the time-course of changes in airway symptoms, responsiveness, inflammation and remodeling after cessation of training

Condition or disease
Asthma Airway Hyperresponsiveness

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Study Type : Observational
Estimated Enrollment : 100 participants
Observational Model: Case-Control
Time Perspective: Prospective
Official Title: Airway Dysfunction and Remodelling in Athletes Following Swimming Training in Chlorinated Pools
Study Start Date : March 2007
Estimated Primary Completion Date : May 2009
Estimated Study Completion Date : May 2009

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Asthma

Swimmers without AHR
Swimmers with asymptomatic AHR
Swimmers with symptomatic AHR and use only of beta-2 adrenargic
Swimmers with asthma and inhaled corticosteroids
Healthy Subjects
Healthy subjects with AHR
Healthy subjects with symptomatic AHR (asthma) but without treatment

Primary Outcome Measures :
  1. Asthma and airway hyperreactivity prevalence in swimmers [ Time Frame: 3 measurements in the year ]

Secondary Outcome Measures :
  1. Airway inflammation and remodeling in swimmers [ Time Frame: 3 measurements in the year and a bronchial biopsy ]

Biospecimen Retention:   Samples With DNA
Serum, plasma, bronchial biopsies

Information from the National Library of Medicine

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Ages Eligible for Study:   14 Years to 35 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Swimmers from Quebec swimming school and universities Control from université Laval or secondary School

Inclusion Criteria:

  • 14 to 35 years old
  • To swim at least 10h per week
  • For control subjects, non-competitive healthy subjects

Exclusion Criteria:

  • any disease that may interfere with the tests for the controls
  • Triathletes are excluded
  • Smokers
  • Obese or with a BMI more than 29
  • Former athletes (control group)

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00686452

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Contact: Valérie BOUGAULT, PhD 418-656-8711 ext 1507
Contact: Louis-Philippe BOULET, MD 418-656-4747

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Canada, Quebec
Centre de recherche en pneumologie et en cardiologie de l'hôpital Laval Recruiting
Québec, Quebec, Canada, G1V4G5
Contact: Valerie BOUGAULT, PhD    418-656-8711 ext 1507   
Contact: Louis-Philippe BOULET, MD   
Principal Investigator: Louis-Philippe BOULET, MD         
Sponsors and Collaborators
Laval University
Publications automatically indexed to this study by Identifier (NCT Number):
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Responsible Party: Dr Louis-Philippe BOULET, MD, Hôpital Laval Identifier: NCT00686452    
Other Study ID Numbers: CER20159
First Posted: May 29, 2008    Key Record Dates
Last Update Posted: December 22, 2008
Last Verified: May 2008
Keywords provided by Laval University:
Airway hyperresponsiveness
Airway inflammation
Airway remodelling
Additional relevant MeSH terms:
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Respiratory Hypersensitivity
Respiratory Tract Diseases
Hypersensitivity, Immediate
Immune System Diseases