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An Open-Label Study to Evaluate the Safety and Efficacy of PRX-08066 in Patients With Pulmonary Hypertension and Chronic Obstructive Pulmonary Disease

This study has been terminated.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00677872
First Posted: May 15, 2008
Last Update Posted: July 30, 2009
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Epix Pharmaceuticals, Inc.
  Purpose
A 3-month open label study to evaluate the safety and efficacy of PRX-08066 in patients with pulmonary hypertension and COPD.

Condition Intervention Phase
COPD Pulmonary Hypertension Drug: PRX-08066 Phase 2

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment

Resource links provided by NLM:


Further study details as provided by Epix Pharmaceuticals, Inc.:

Primary Outcome Measures:
  • Six-minute walk test (6-MWT)and mean pulmonary artery pressure (MPAP) utilizing right heart catheterization.

Secondary Outcome Measures:
  • Central hemodynamic and exercise capacity parameters utilizing RHC and CPET

Estimated Enrollment: 40
Study Start Date: May 2008
Estimated Primary Completion Date: December 2008 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: 1 Drug: PRX-08066

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   40 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Men and Women >40 years of age
  • Diagnosis of COPD with an FEV1 above 20% and less than 65% of predicted normal and an FEV1-to-FVC ratio of less than 70%
  • Diagnosis of pulmonary hypertension based on echocardiography within the last 6 months or by cardiac catheterization within the last 12 months
  • New York Heart Association(NYHA)Class II or III
  • Screening LVEF>55%, obtained by any appropriate method within 6 months of screening
  • Baseline 6MWT distance>150m and <450m
  • Written informed consent from each subject prior to the initiation of any study-related procedure
  • Documented negative results (within 12 months)and Hepatitis B and Hepatitis C Serology

Exclusion Criteria:

  • Treatment for pulmonary hypertension with epoprostenol (prostacyclin), trepostinil (Remodulin), iloprost (Ventavis), bosentan (Tracleer), ambrisentan (Letairis), sildenafil (Viagra), tadalafil (Cialis), or vardenafil (Levitra) within the 30 days prior to study entry
  • Presence or history of any of the following cardiovascular co-morbidities or conditions: Un-controlled systemic hypertension at screening; unstable cardiovascular disease including intermittent atrial fibrillation or unstable angina within the 4 weeks prior to screening; amyloidosis, hypertrophic obstructive cardiomyopathy, restrictive cardiomyopathy, or constrictive pericarditis; history of myocardial infarction, coronary artery bypass graft surgery, or percutaneous cardiac intervention within the 3 months prior to screening; significant valvular heart disease; cerebrovascular accident or transient ischemic attack within 3 months prior to screening
  • COPD exacerbation less than 1 month prior to screening
  • Exercise tolerance limited by non-cardiac causes
  • Clinically significant psychiatric, addictive, neurologic disease or condition
  • Chronic renal impairment or renal insufficiency
  • No clinically significant laboratory abnormalities
  • Subjects currently being treated for PH with prostnoids, PDE-5 inhibitors and or endothelin receptor antagonist. The use of PDE-5 inhibitors "as needed" for erectile dysfunction is acceptable as long as the subject does not take the medication within 72 hours of an efficacy assessment. Other concomitant medications are allowed provided the subject has been on a stable dose regimen for at least 4 weeks prior to enrollment and the regimen continues and remains stable during the treatment and follow-up periods.
  • History of nasal airway mass, septal perforation, chronic sinusitis, lidocaine allergy or current nasal passage condition that would decrease the safety or tolerability of a naso-esophageal catheter
  • The subject has the presence, or history, of malignancy that required significant medical intervention within the preceding 3 months and/or is likely to result in death within the next 2 years
  • The receipt of any investigational medication within 30 days prior to screening or anytime during the course of the study
  • Women cannot be pregnant or breastfeeding
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00677872


Locations
United States, Massachusetts
Massachusetts General Hospital Pulmonary and Critical Care Unit
Boston, Massachusetts, United States, 02114
Sponsors and Collaborators
Epix Pharmaceuticals, Inc.
  More Information

Responsible Party: Elkan Gamzu, PhD, EPIX Pharmaceuticals, Inc.
ClinicalTrials.gov Identifier: NCT00677872     History of Changes
Other Study ID Numbers: PRX-08066-202
First Submitted: May 13, 2008
First Posted: May 15, 2008
Last Update Posted: July 30, 2009
Last Verified: July 2009

Keywords provided by Epix Pharmaceuticals, Inc.:
Moderate to severe COPD and coincident pulmonary hypertension

Additional relevant MeSH terms:
Hypertension
Pulmonary Disease, Chronic Obstructive
Hypertension, Pulmonary
Vascular Diseases
Cardiovascular Diseases
Lung Diseases, Obstructive
Lung Diseases
Respiratory Tract Diseases