HIV Vertical Transmission in Vietnam
|ClinicalTrials.gov Identifier: NCT00669604|
Recruitment Status : Completed
First Posted : April 30, 2008
Last Update Posted : April 30, 2008
|Condition or disease|
Observation 135 HIV mother to check up and delivery in the Obstetric and Gynecology in two big city in Northern Vietnam (Hanoi and Haiphong)and follow up their children from the birth to 18 months. They were provide the antiretroviral by the National program for prevention of mother-to-child transmission of HIV, also the counseling estimates 6 hours for each mother-child pair while study progressing. Using the Nested PCR to diagnosis HIV infected in the children in difference time point before 18 months. Our Outcome are
- The rate of HIV transmission form mother to child in our study is 6,7%(9?135). In utero is 1,5% and 5% in gestation.
- Sixty-nine percent of HIV pregnant women were get antiretroviral. Most of them (84%) get nevirapine at delivery (6 children HIV infected). The rest get triple antiretroviral(2 infected child).
- Selective cesarean section not comment for HIV pregnant women.
- Non breast feeding were recommended and all mothers chose formula feeding to their child so that we had no data for transmission by breast milk.
- Two HIV infected child die before 18months versus non die in uninfected child.
- CD4 T cell count lower than 200/microliter were observed dominate in mother infected child.
|Study Type :||Observational|
|Actual Enrollment :||135 participants|
|Official Title:||Counseling on Formula Feeding and Antiretroviral Prophylaxis Successfully Reduced Transmission of HIV-1 From Mother to Child in Northern Vietnam|
|Study Start Date :||March 2004|
|Actual Primary Completion Date :||December 2007|
|Actual Study Completion Date :||December 2007|
- HIV-infection in the children. [ Time Frame: 2004 - 2007 ]
- Mortality in the children in the first 18 months [ Time Frame: completed 2007 ]
- Safety of formula feeding measured by the mortality by 18 months [ Time Frame: Completed by end of 2007 ]
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00669604
|Obstetric and Gynaecology Hospital|
|Hanoi, Vietnam, 10000|
|Study Chair:||Phung D Cam, MD,PhD||National Institute of Hygiene and Epidemiology, Vietnam|